Results 271 to 280 of about 97,027 (306)

Defining the dynamics of self-assembled Fas-receptor activation

Trends in Immunology, 2002
Fas-Fas-ligand, the most well investigated apoptotic signaling system, plays a pivotal role in several human diseases. Its signaling through multiple pathways; multiple, complex regulatory points; and recently described tendency to undergo ligand-independent self-assembly warrant a comprehensive understanding of its physiologically well controlled ...
Suneel D, Mundle, Azra, Raza
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Fas receptor-mediated apoptosis

The Journal of Pathology, 2002
Fas is a membrane protein belonging to the death receptor family. Cross-linking of Fas by its ligand, FasL, or agonistic anti-Fas antibodies, induces apoptosis of cells expressing Fas on the membrane by triggering a cascade of caspases. Since many different tumours express Fas on their membrane, targeting Fas-mediated apoptosis by anti-Fas antibodies ...
Timmer, T, de Vries, EGE, de Jong, S
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Fas and Fas Ligand: A Death Factor and Its Receptor

1994
Publisher Summary This chapter discusses the Fas /Fas ligand system and its physiological role. The chapter discusses the identification of a natural Fas ligand in a cytotoxic T-lymphocyte (CTL) cell line and proves that it is a member of the tumor necrosis factor (TNF) family.
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Apoptosis regulated by a death factor and its receptor: Fas ligand and Fas

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1994
Homeostasis in vertebrates is tightly regulated by not only proliferation and differentiation of cells, but also cell death or apoptosis (Elliset al.1991; Raff 1992). Many cytokines bind to their respective receptors to regulate proliferation and differentiation of cells. Our recent studies on the Fas ligand and Fas indicate that they work respectively
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Fas receptor signaling is requisite for B cell differentiation

Journal of Leukocyte Biology, 2005
AbstractThe Fas/Fas ligand (FasL) pathway has been largely implicated in the homeostasis of mature cells. However, it is still unclear whether it plays a role at the progenitor level. To address this issue, we created chimeric mice by transferring C57BL/6 bone marrow (BM) cells of the lpr (Fas−FasL+) or gld (Fas+FasL−) genotype into Rag-2−/− hosts of ...
Pasqualetto, Valérie, Vasseur, Florence, Zavala, Flora, Schneider, Elke, Ezine, Sophie   +4 more
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Fas receptor expression on asthmatic eosinophils.

Research communications in molecular pathology and pharmacology, 1999
Activation of the Fas receptor (Fas; CD95) on eosinophils induces apoptosis and may play a role in controlling eosinophil number in blood and tissue. To determine whether Fas expression on eosinophils is different between asthmatics and non-asthmatics, eosinophils were isolated from the peripheral blood using a three-step procedure of dextran ...
J E, Fahy, S F, Quan, J W, Bloom, M J, Halonen   +3 more
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Surface T cell Fas receptor/CD95 regulation, in vivo activation, and apoptosis. Activation-induced death can occur without Fas receptor

The Journal of Immunology, 1996
Abstract Fas-mediated apoptosis is a form of cell death that operates through a receptor-ligand interaction. The FasR has been implicated directly in peripheral T cell tolerance and activation-induced apoptosis of T cells in vitro, although to date its expression on murine peripheral T cells has been characterized incompletely.
C L, Tucek-Szabo, S, Andjelić, E, Lacy, K B, Elkon, J, Nikolić-Zugić   +4 more
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In Vivo Inhibition of Fas Ligand-Mediated Killing by TR6, a Fas Ligand Decoy Receptor

The Journal of Pharmacology and Experimental Therapeutics, 2001
TR6, a member of the tumor necrosis factor (TNF) receptor superfamily, has recently been shown to bind to Fas ligand (FasL) and inhibit FasL-mediated cell killing in vitro. In the current study, we demonstrate that TR6 can block the lethal activity of FasL in multiple in vitro systems, and extend this finding to an in vivo model of hepatitis.
K, Connolly, Y H, Cho, R, Duan, J, Fikes, T, Gregorio, D W, LaFleur, Z, Okoye, T W, Salcedo, G, Santiago, S, Ullrich, P, Wei, K, Windle, E, Wong, X T, Yao, Y Q, Zhang, G, Zheng, P A, Moore   +16 more
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Phenotype-Linked Amino Acid Alteration in Leptin Receptor cDNA from Zucker Fatty(fa/fa)Rat

Biochemical and Biophysical Research Communications, 1996
The mouse obese (ob) gene product (leptin), expressed specifically in adipose cells, regulates energy balance in mice. Both mouse diabetes (db) and rat fatty (fa) gene products are thought to play major roles in leptin signaling pathways in the hypothalamic area.
M, Iida, T, Murakami, K, Ishida, A, Mizuno, M, Kuwajima, K, Shima   +5 more
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The Fas/APO-1 receptor and its deadly ligand

Trends in Cell Biology, 1994
The cell surface receptor Fas/APO-1 and its ligand have recently been identified as important mediators of apoptosis. Both molecules are crucial for the maintenance of a sound immune system, and when defective they give rise to severe autoimmune disorders.
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