Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice [PDF]
, 2016 Cell death by apoptosis has a critical role during embryonic development and in maintaining tissue homeostasis. In mammals, there are two converging apoptosis pathways: the ‘extrinsic’ pathway, which is triggered by engagement of cell surface ‘death ...
A Egle +65 more
core +3 more sources
Estrous cycle-dependent changes of Fas expression in the bovine corpus luteum: influence of keratin 8/18 intermediate filaments and cytokines [PDF]
, 2012 Background Fas expression and Fas-induced apoptosis are mechanisms attributed to the selective destruction of cells of the corpus luteum (CL) during luteal regression.
Birt, Alyssa +3 more
core +2 more sources
Active Few-Shot Learning with FASL
, 2022 Recent advances in natural language processing (NLP) have led to strong text classification models for many tasks. However, still often thousands of examples are needed to train models with good quality. This makes it challenging to quickly develop and deploy new models for real world problems and business needs.
Thomas Müller +3 more
openaire +2 more sources
Plasma Levels of sFas-sFasL and FASL Gene Expression Are Associated with Tuberculosis
Biomolecules, 2022 Apoptosis of macrophages infected by Mycobacterium tuberculosis via Fas-FasL is an important immune mechanism against infection. This study investigated the association of tuberculosis (TB) with the presence of the polymorphisms FAS -670A/G and FASL ...
Iury de Paula Souza +8 more
doaj +1 more source
Autoimmune lymphoproliferative syndrome in pregnancy: a case of favorable mother - fetal outcome in a well-controlled disease [PDF]
, 2014 The autoimmune lymphoproliferative syndrome(ALPS)is a disorder of abnormal lymphocyte survival caused by the dysregulation of theFasapoptotic pathway. The Fas geneis expressed at the maternal–fetal interface and is involved in the regulation of immune ...
Baek +14 more
core +1 more source
The role of FasR/FasL system in pathogenesis of myeloprolyferative neoplasms [PDF]
Archives of Biological Sciences, 2010 Myeloproliferative neoplasms (MPN) are hematological malignancies characterized by uncontrolled cell proliferation and impaired apoptosis. The FasR/FasL system is involved in the control of apoptosis in different cell types. Here we have investigated the
Spasovski Vesna +6 more
doaj +1 more source
Systemic FasL and TRAIL neutralisation reduce leishmaniasis induced skin ulceration. [PDF]
PLoS Neglected Tropical Diseases, 2010 Cutaneous leishmaniasis (CL) is caused by Leishmania infection of dermal macrophages and is associated with chronic inflammation of the skin. L. aethiopica infection displays two clinical manifestations, firstly ulcerative disease, correlated to a ...
Geremew Tasew +12 more
doaj +1 more source
Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection. [PDF]
, 2012 Monocytes and T-cells are critical to the host response to acute bacterial infection but monocytes are primarily viewed as amplifying the inflammatory signal.
A Kadioglu +64 more
core +4 more sources
CTLA-4 · FasL Induces Alloantigen-Specific Hyporesponsiveness [PDF]
The Journal of Immunology, 2003 AbstractThe APC:T cell interface can be effectively targeted with immunotherapeutic proteins. We previously described a unique trans signal converter protein, CTLA-4 · Fas ligand (FasL), that has the inherent capacities to tether the T cell inhibitor FasL (CD95 ligand) to the surfaces of B7 (CD80 and CD86)-positive APC (via CTLA-4:B7 interaction), and ...
Michal Dranitzki, Elhalel +4 more
openaire +2 more sources
miRNA-19a exerts an anti-apoptotic effect in spinal cord injured rats via the PTEN pathway
Archives of Medical Science, 2019 Introduction Contusion spinal cord injury is involved in a number of cellular, biochemical and molecular changes. We studied the overall expression pattern of miRNAs on day 1 and 3 after spinal cord injury and the involved pathways.
Lu Chen +4 more
doaj +1 more source