Results 41 to 50 of about 61,337 (245)

VEGF(164)-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization [PDF]

, 2003
Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological retinal neovascularization. In the current paper, the mechanisms of physiological and pathological neovascularization are compared and contrasted.
Adamis, AP, Amano, S, Ambati, J, D'Amore, PA, Gragoudas, ES, Hida, T, Ishida, S, Kaji, Y, Miller, JW, Ng, YS, Oguchi, Y, Ogura, Y, Shima, DT, Usui, T, Yamashiro, K   +14 more
core   +1 more source

JAK-STAT-mediated chronic inflammation impairs cytotoxic T lymphocyte activation to decrease anti-PD-1 immunotherapy efficacy in pancreatic cancer

OncoImmunology, 2017
Human pancreatic cancer does not respond to immune check point blockade immunotherapy. One key feature of pancreatic cancer is the association between its progression and chronic inflammation.
Chunwan Lu, Asif Talukder, Natasha M. Savage, Nagendra Singh, Kebin Liu   +4 more
doaj   +1 more source

CHARACTERISTICS OF SIGNALING PATHWAYS MEDIATING A CYTOTOXIC EFFECT OF DENDRITIC CELLS UPON ACTIVATED Т LYMPHOCYTES AND NK CELLS

Медицинская иммунология, 2014
. Cytotoxic/pro-apoptogenic effects of IFNα-induced dendritic cells (IFN-DCs) directed against Т-lymphocytes and NK cells were investigated in healthy donors.
T. V. Tyrinova, O. Yu. Leplina, M. A. Tikhonova, L. V. Sakhno, A. A. Ostanin, E. R. Chernykh   +5 more
doaj   +1 more source

CD4+T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C viruscoinfected patients [PDF]

, 2017
To characterize peripheral blood natural killer (NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients.
Cahn, Pedro, Laufer, Natalia Lorna, Martinez, Ana, Ojeda, Diego Sebastian, Polo, Maria Laura, Pérez, Héctor, Quarleri, Jorge Fabian, Turk, Gabriela Julia Ana, Zwirner, Norberto Walter   +8 more
core   +1 more source

Differential expression of Fas receptors (CD95) and Fas ligands (CD95L) in HIV infected and exposed uninfected children in Cameroon versus unexposed children

The Pan African Medical Journal, 2019
INTRODUCTION: The number of HIV exposed uninfected (HEU) infants is increasing as vertical transmission is reducing. This subpopulation requires more investigations.
Béatrice Dambaya, Céline Nguefeu Nkenfou, Georgia Ambada, George Mondinde Ikomey, Linda Mekue Mouafo, Nicole Ngoufack, Elvis Ndukong Ndzi, Georges Této, Aubin Nanfack, Nelson Sonela, Joseph Fokam, Njiokou Flobert, Vittorio Colizzi, Alexis Ndjolo   +13 more
doaj   +1 more source

Impact of cell death pathway genes Fas 21377AA and FasL 2844CC polymorphisms on the risk of developing non-small cell lung cancer

Egyptian Journal of Medical Human Genetics, 2018
Background: The signalling pathway Fas and FasL system plays a fundamental role in the regulation of apoptotic cell death and any disturbance of this pathway has been shown to promote immune escape and tumorigenesis.
Nada Ezzeldin, Hebatallah Farouk, Dina M. Kandil, Amira Darwish, Ahmed El-Bastawisy   +4 more
doaj   +1 more source

Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL [PDF]

, 2012
Decidual macrophages (DM) are the second most abundant population in the fetal-maternal interface. Their role has been so far identified as being local immuno-modulators favoring the maternal tolerance to the fetus.
Angioni, Antonis Makrigiannakis, Barnea, Birgit Bayer, Borges, Chieppa, Dace, Darius Dian, David Anz, Devaraj, Dockrell, Gordon, Gustafsson, Heikkinen, Houser, Iordanis Navrozoglou, Julia Knabl, Klaus Friese, Macklon, Makrigiannakis, Mills, Minas, Miwa, Mizuno, Munn, Nagamatsu, Nagata, Parhar, Pestka, Piccinni, Quack, Renaud, Sabine Guenther, Sabine Heublein, Saito, Sica, Thomas Vrekoussis, Udo Jeschke, Vassiliadou, Warning, Wongweragiat, Yagel   +41 more
core   +2 more sources

FasR and FasL in colorectal cancer

International Journal of Oncology, 2017
Colorectal cancer (CRC) is one of the most common solid organ cancers prevalent worldwide causing, in spite of advancing therapeutic methodology, high rate of patient mortality, especially due to metastasis development. The cancer stem cell (CSC) theory of tumor growth indicates that CSCs within the tumor mass have great capacity to initiate and ...
Magdalena, Szarynska, Agata, Olejniczak, Piotr, Wierzbicki, Jaroslaw, Kobiela, Dariusz, Laski, Zbigniew, Sledzinski, Krystian, Adrych, Marek, Guzek, Zbigniew, Kmiec   +8 more
openaire   +3 more sources

Matrix metalloproteinase/Fas ligand (MMP/FasL) interaction dynamics in COVID-19: An in silico study and neuroimmune perspective

Heliyon
Background: The initiator of cytokine storm in Coronavirus disease (COVID-19) is still unknown. We recently suggested a complex interaction of matrix metalloproteinases (MMPs), Fas ligand (FasL), and viral entry factors could be responsible for the ...
Kiarash Saleki, Cena Aram, Parsa Alijanizadeh, Mohammad Hossein Khanmirzaei, Zahra Vaziri, Mohammad Ramzankhah, Abbas Azadmehr   +6 more
doaj   +1 more source

Opposing roles for membrane bound and soluble Fas ligand in glaucoma-associated retinal ganglion cell death. [PDF]

PLoS ONE, 2011
Glaucoma, the most frequent optic neuropathy, is a leading cause of blindness worldwide. Death of retinal ganglion cells (RGCs) occurs in all forms of glaucoma and accounts for the loss of vision, however the molecular mechanisms that cause RGC loss ...
Meredith S Gregory, Caroline G Hackett, Emma F Abernathy, Karen S Lee, Rebecca R Saff, Andreas M Hohlbaum, Krishna-Sulayman L Moody, Maura W Hobson, Alexander Jones, Paraskevi Kolovou, Saoussen Karray, Andrea Giani, Simon W M John, Dong Feng Chen, Ann Marshak-Rothstein, Bruce R Ksander   +15 more
doaj   +1 more source