Results 111 to 120 of about 10,265,437 (389)

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Facebook | Panopticon: an analysis of Facebook and its parallels to the Foucaultian Panopticon [PDF]

open access: yes, 2015
A panopticon—the ideal mechanism for surveillance and control—has become embedded in our smartphones and our web browsers. It now pervades the fabric of approximately 890 million daily lives. It is called Facebook.
Fast, Stephanie A.
core   +1 more source

Locking fast

open access: yesProceedings of the 29th Annual ACM Symposium on Applied Computing, 2014
Cet article présente trois techniques pour utiliser plus efficacement les moniteurs dans les langages de programmation.
Serrano, Manuel, Grande, Johan
openaire   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

Non-Destructive Detection of Tea Polyphenols in Fu Brick Tea Based on Hyperspectral Imaging and Improved PKO-SVR Method

open access: yesAgriculture
Tea polyphenols (TPs) are a critical indicator for evaluating the quality of tea leaves and are esteemed for their beneficial effects. The non-destructive detection of this component is essential for enhancing precise control in tea production and ...
Junyao Gong   +4 more
doaj   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

open access: yesFEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield   +3 more
wiley   +1 more source

GetOrganelle: a fast and versatile toolkit for accurate de novo assembly of organelle genomes

open access: yesGenome Biology, 2018
GetOrganelle is a state-of-the-art toolkit to accurately assemble organelle genomes from whole genome sequencing data. It recruits organelle-associated reads using a modified “baiting and iterative mapping” approach, conducts de novo assembly, filters ...
Jianjun Jin   +6 more
semanticscholar   +1 more source

Excited by fasting? NO [PDF]

open access: yesThe Journal of Physiology, 2014
Nitric oxide (NO) has multiple effects within the gastrointestinal (GI) system, including modulation of GI motility, mucosal function, inflammation and blood flow, as well as the excitability and responsiveness of vagal sensory afferents as well as vagal efferents. In this issue of The Journal of Physiology Kentish et al.
openaire   +3 more sources

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

open access: yesFEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan   +2 more
wiley   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

open access: yesFEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile   +8 more
wiley   +1 more source

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