Results 61 to 70 of about 1,322,387 (339)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Journal of Virus Eradication, 2019 Objectives: The relationship between lipid levels in plasma and inflammatory indices is complex and fatty meals alter plasma inflammatory markers in people with diabetes. There is interest in monitoring the effects of interventions on plasma inflammatory
Dominic Dorazio +11 more
doaj +1 more source
Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα [PDF]
, 2016 Adaptation to fasting involves both Glucocorticoid Receptor (GRα) and Peroxisome Proliferator-Activated Receptor α (PPARα) activation. Given both receptors can physically interact we investigated the possibility of a genome-wide cross-talk between ...
Bougarne, Nadia +14 more
core +3 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Ramadan, the month of fasting [PDF]
, 2008 Socially, fasting is an expression of unity with the poor, the family, and the whole society. This is a period in which the rich have first-hand experience of what it is to be poor, the pains the needy suffers in normal living conditions.
Sahar, Nadima
core +1 more source
Exoskeletons need to react faster than physiological responses to improve standing balance [PDF]
, 2023 Owen N. Beck +5 more
openalex +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Optimizing a Standard Fasting Time for 2-NBDG Uptake Studies in Murine Breast Cancers [PDF]
, 2017 Recently, there has been a larger use of 2-NBDG, a fluorescent glucose analog, to study glucose uptake in different cell types. These cell types have ranged anywhere from bacteria to human cancer cells.
Briley, Andrew C
core +2 more sources
Proceedings of the 29th Annual ACM Symposium on Applied Computing, 2014 Cet article présente trois techniques pour utiliser plus efficacement les moniteurs dans les langages de programmation.
Serrano, Manuel, Grande, Johan
openaire +2 more sources