Results 201 to 210 of about 696,395 (294)

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

open access: yesProteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1686-1701, October 2026.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva   +10 more
wiley   +1 more source

Incorporation of Natural Antimicrobial Agents Into Thermoplastic Polymers for Food Applications: Strategies, Efficacy, Challenges and Future Directions

open access: yesPackaging Technology and Science, Volume 39, Issue 10, Page 1253-1279, October 2026.
This graphical abstract summarizes the main strategies for incorporating natural antimicrobial agents into thermoplastic food packaging polymers, including melt processing, surface deposition, controlled release and chemical immobilization. It highlights the major classes of natural antimicrobials, key advantages such as microbial growth reduction and ...
Florence Akinmeye   +4 more
wiley   +1 more source

Structural and Functional Characterisation of a Metagenome‐Derived CYP108D18 Reveals an Unusual Dioxygen‐Bound State and Selective Hydrocarbon Hydroxylation

open access: yesMicrobial Biotechnology, Volume 19, Issue 10, October 2026.
CYP108D18, identified from a hot spring metagenome, catalyses selective phenylcyclohexane hydroxylation. This P450 has an exceptionally low substrate‐bound heme redox potential. Crystal structures revealed an unusual dioxygen‐bound substrate‐free form and a persistent open active site upon substrate binding.
Simran Kundral   +10 more
wiley   +1 more source

Biofilm Source Shapes the Tolerance to Short‐Term Ciprofloxacin Exposure

open access: yesEnvironmental Microbiology Reports, Volume 18, Issue 5, October 2026.
Biofilms sourced downstream of a wastewater treatment plant showed greater tolerance to ciprofloxacin than upstream‐sourced communities. The results suggest that environmental history and community composition influence freshwater biofilm responses to antibiotic stress.
Clara Benavent‐Celma   +6 more
wiley   +1 more source

uPAR‐Targeting T Cell Engager Exerts Senolytic Effects in Mice and Non‐Human Primates With Serum Aminotransferase Activity as a Safety Monitor

open access: yesAging Cell, Volume 25, Issue 10, October 2026.
GFD‐CD3, a uPAR‐targeting T‐cell engager, effectively cleared senescent cells and mitigated age‐related pathologies with a favorable safety profile under transaminase‐guided monitoring. ABSTRACT Senolytic CAR‐T cells targeting uPAR induce dose‐dependent toxicities.
Jian Deng   +13 more
wiley   +1 more source

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