Results 71 to 80 of about 6,022,993 (297)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Relative effects of weight loss and dietary fat modification on serum lipid levels in the dietary treatment of obesity.

Journal of Lipid Research, 1993
The independent effects of weight loss and dietary fat modification on serum lipids were investigated in two groups of healthy moderately obese men and women.
R Leenen, K van der Kooy, S Meyboom, JC Seidell, P Deurenberg, JA Weststrate   +5 more
doaj   +1 more source

Effect of Weight Loss on Upper Airway Anatomy and the Apnea Hypopnea Index: The Importance of Tongue Fat.

American Journal of Respiratory and Critical Care Medicine, 2020
RATIONALE Obesity is the primary risk factor for sleep apnea (OSA). Tongue fat is increased in obese persons with OSA, and may explain the relationship between obesity and OSA. Weight loss improves OSA, but the mechanism is unknown.
Stephen H Wang, B. Keenan, A. Wiemken, Y. Zang, B. Staley, D. Sarwer, D. Torigian, N. Williams, A. Pack, R. Schwab   +9 more
semanticscholar   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

The Acute Effects of a Commercially Available Caffeinated and Caffeine-Free Thermogenic Dietary Supplement on Resting Energy Expenditure, Hunger, and Hemodynamic Responses

Nutraceuticals
There has been a rise in popularity of “stimulant-free” or caffeine-free fat loss supplements, but it is not well understood whether those fat loss supplements are effective at enhancing thermogenesis without caffeine’s influence.
Kworweinski Lafontant, Jacob Broeckel, Kara Phillips, Yasamian Alsayed, Wayne A. Ayers-Creech, Yuto Ohigashi, John Solis, Cassidy Bale, Arielle Parks, Scott Dankel, Bill I. Campbell   +10 more
doaj   +1 more source

Calorie for calorie, dietary fat restriction results in more body fat loss than carbohydrate restriction in people with obesity

Cell Metabolism, 2015
Summary Dietary carbohydrate restriction has been purported to cause endocrine adaptations that promote body fat loss more than dietary fat restriction. We selectively restricted dietary carbohydrate versus fat for 6 days following a 5 day baseline diet ...
K. Hall, Thomas Bemis, R. Brychta, Kong Y. Chen, A. Courville, Emma J Crayner, Stephanie K. Goodwin, Juen Guo, Lilian Howard, N. Knuth, Bernard V. Miller, C. Prado, M. Siervo, M. Skarulis, M. Walter, P. Walter, Laura E. Yannai   +16 more
semanticscholar   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Effect of diet with or without exercise on abdominal fat in postmenopausal women – a randomised trial

BMC Public Health, 2019
Background We assessed the effect of equivalent weight loss with or without exercise on (intra-) abdominal fat in postmenopausal women in the SHAPE-2 study.
Willemijn A. van Gemert, Petra H. Peeters, Anne M. May, Adriaan J. H. Doornbos, Sjoerd G. Elias, Job van der Palen, Wouter Veldhuis, Maaike Stapper, Jantine A. Schuit, Evelyn M. Monninkhof   +9 more
doaj   +1 more source