Results 71 to 80 of about 3,565,947 (256)
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution [PDF]
, 2010 Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified.Lawrence, Robert W, Shengxu Li, Ridker, P.M., Assimes, Themistocles L., Ingelsson, E., Van Meurs, JBJ, Sanna, Serena, Welch, R, Christopher C Holmes, Teslovich, Tanya M., Boerwinkle, E., Anneli Pouta, Qi, L., Knowles, JW, Hicks, Andrew A, Palmer, L.J., Hengstenberg, Christian, Nelis, M, Mari Nelis, Glazer, NL, Kapur, K. (Karen), Tiinamaija Tuomi, Christine Cavalcanti-Proença, Smith, AV, Visscher, H.M., Day, I.N.M., Steven A McCarroll, Kaprio, Jaakko, Antti Jula, Qi, Lu, Monda, Keri L., Perry, J.R., Thomas A Buchanan, Lawrence, Robert W., Platou, C.P. (Carl), Geus, E.J., Froguel, P. (Philippe), Stefansson, K, Willemsen, G.A.H.M. (Gonneke), Palmer, Lyle J., Frayling, Timothy M., Wichmann, H.E. (Heinz Erich), Kinnunen, L, Nicholson, G., Igl, W., Harris, T.B. (Tamara), Haritunians, T. (Talin), Quertermous, T., Grassler, J., Atwood, Larry D, Smit, J.H., James, A. (Alan), Vatin, V, Kilpeläinen, T.O., Munroe, PB, Cupples, L.A. (Adrienne), Nigel W Rayner, Qi, L, Ludwig, Barbara, Smith, GD, Rivadeneira, F, Eero Kajantie, Gonçalo R Abecasis, Gyllensten, Ulf,, Strachan, David P., Ong, KK, McKknight, B. (Barbara), Johnson, T, Penninx, B.W.J.H., Rudan, I. (Igor), Krzelj, V., Workalemahu, Tsegaselassie, Gjesing, A.P. (Anette), Shaun Purcell, Kajantie, E, Peter S Chines, et al., Joshua W Knowles, Smith, A.V. (Albert Vernon), Alan L James, Herzig, KH, Tammesoo, M.L., Dixon, A.L., Mariano Dei, Vitart, Veronique, Völzke, H. (Henry), Johannes Kettunen, Iribarren, Carlos, Johansson, Åsa,, Kolcic, I. (Ivana), Cupples, L.A., Ketkar, S, Lettre, G, Morris, AP, Christian Hengstenberg, Wright, A.F., Kilpeläinen, TO, Jaakko Tuomilehto, Robertson, N.R., Ong, K.K., Lachlan Coin, Lee M Kaplan, Weedon, Michael N., Wareham, N.J., Molony, C., Ulf Gyllensten, Wingerden, K.M.C. van, Wild, S.H. (Sarah), Ridderstråle, Martin,, van Ommen, GJ, Weyant, R.J., Zgaga, L, Illig, T., Swift, A.J. (Amy), Watanabe, R.M. (Richard), Barbara McKnight, Nyholt, D.R., Visscher, PM, Hicks, Andrew A., Monda, K.L., Jackson, A.U., Andrew P Morris, Marre, M, Ben Oostra, Oskari Kilpeläinen, Tuomas, Pietiläinen, Kirsi H, Wilson, James F, Jennie Hui, Ian N M Day, Peters, Marjolein, Gaget, Stefan, Tönjes, A. (Anke), Bornstein, SR, Iris M Heid, Völzke, H, Ridderstråle, M. (Martin), Parker, AN, Syvänen, Ann-Christine,, Ripatti, S., Johan G Eriksson, Wallaschofski, Henri, de Geus, EJC, Heard-Costa, Nancy L., Wright, AF, Hottenga, J.J., Wood, Andrew R, Peter M Visscher, Palmer, LJ, Beckmann, Jacques S, Hicks, A.A., Geus, Eco JC, Almgren, P. (Peter), Hirschhorn, J.N. (Joel), Syvanen, A.C., Stumvoll, M. (Michael), Polasek, Ozren, M Carola Zillikens, Thorsteinsdottir, U, Hui, J.N., Ruth J F Loos, Jarvelin, MR, Dixon, Anna L., Salomaa, V. (Veikko), van Duijn, Cornelia M., Thorsteinsdottir, U. (Unnur), Miriam F Moffatt, Kao, WHL, Eriksson, J.G., Groop, L. (Leif), Winkler, T.W., Jackson, Anne U, Walters, G. Bragi, Jorgensen, T., Ferreira, T., Barroso, Ines, Ann-Christine Syvanen, Goddard, M.E. (Michael), Collins, FS, Thor Aspelund, Heard-Costa, NL, Kulzer, Jennifer R, Zhao, JH, Kuusisto, J. (Johanna), Laakso, M. (Markku), Kaplan, R.C., Pramstaller, PP, Volzke, H., Tuomi, T., Rissanen, A, Vollenweider, P, Wilmar Igl, Pouta, A. (Anneli), Buchanan, Thomas A., Cavalcanti-Proença, C. (Christine), Visscher, Peter M., Kutalik, Z. (Zoltán), Barroso, I.E. (Inês), Elisabeth Widen, Elliott, P., Witteman, Jacqueline C, Eco J C Geus, North, KE, Wheeler, Eleanor, Nyholt, DR, Yang, JA, Pietilainen, K.H. (Kirsi Hannele), Marjo-Riitta Jarvelin, Spector, Timothy D, Duijn, C.M. (Cornelia) van, Richard N Bergman, Psaty, Bruce M., Mägi, R., Beilby, John P, Walters, G Bragi, Tuomilehto, J., Jürgen Gräßler, Swift, Amy J, Fu, M, Jørgensen, T., Nicholson, George, Deloukas, P, , M. dei, Vedantam, S. (Sailaja), Hansen, T., Smit, Jan H., Hunter, D.J. (David), Serena Sanna, Heid, I.M. (Iris), Biffar, R., Chasman, D.I. (Daniel), Li, S., Robertson, Neil R, Lango Allen, H., Mohlke, K.L., Campbell, Harry, Bennett, A.J., Teumer, A. (Alexander), Rayner, Nigel W., Voight, Benjamin F, Watanabe, Richard M., Allen, Hana Lango, Atwood, L.D. (Larry), van Ommen, G.J., Dorret I Boomsma, Leena Peltonen, Feitosa, M.F. (Mary Furlan), Zgaga, L. (Lina), Bergmann, S, Grallert, H., Moffatt, M.F., Kari Stefansson, Lawrence, RW, Kraja, A. (Aldi), Steinthorsdottir, V., Khaw, KT, Hartikainen, AL, Li, SX, Hu, Frank B., Oong, K. (Ken), Atwood, Larry D., Ripatti, S, Lindgren, Cecilia M, Hengstenberg, C, Chines, Peter S., Chasman, DI, Smith, G.D., Timothy M Frayling, Vilmundur Gudnason, Fox, C.S., Torben Hansen, Lathrop, G.M. (Mark), Ivana Kolcic, Watanabe, RM, Wilson, J.F., Guiducci, C. (Candace), Samani, N.J., Raitakari, O., Coin, L. (Lachlan), Pedersen, O., Beilby, JP, Fisher, E, Soranzo, N., Zoltán Kutalik, Pouta, A., Widen, Elisabeth, Kahonen, M., Walters, G.B. (Bragi), Perry, JR, Perola, M. (Markus), Wichmann, HE, Li, S. (Shengxu), Vatin, V. (Vincent), James Nemesh, Buchanan, T.A. (Thomas), Pichler, Irene, Silander, Kaisa, Spector, Timothy D., Kovacs, P, Kaprio, J, Bergmann, S., Smit, J.H. (Jan), Midthjell, K. (Kristian), Candace Guiducci, Frayling, Timothy M, Teumer, Alexander, Usala, Gianluca, Illig, T, Cupples, L Adrienne, Zondervan, Krina T., Cupples, L. Adrienne, Peden, John F., Cristen J Willer, Beckmann, J.S. (Jacques), de Geus, E.J.C., Willemsen, G.; id_orcid, Prokopenko, I, Kapur, K., Pietilainen, K.H., Khaw, Kay-Tee, Lecoeur, Cecile, Leitzmann, M.F., Day, I.N., Kristian Hveem, Stefan Gaget, Teslovich, TM, Ferreira, T. (Teresa), Samani, Nilesh J, Peltonen, L. (Leena Johanna), Hattersley, Andrew T, Kraja, Aldi T, Kaisa Silander, Boomsma, Dorret I., McArdle, W.L., Hirschhorn, J.N., Kovacs, Peter, Rissanen, Aila, Zitting, P. (Paavo), Reedik Mägi, Michael N Weedon, Hayward, Caroline, Hofman, A. (Albert), Kaakinen, M., Albert Hofman, Voight, B.F., Amanda J Bennett, Teder-Llaving, M. (Maris), Igl, Wilmar, Ssmith, A.V., Kroemer, H.K., Ryan Welch, Caulfield, MJ, Haritunians, T., Lamina, C, Kaplan, Robert C, Hicks, AA, Kuusisto, Johanna, Aspelund, T, Weedon, MN, Neville, Matt J., Rayner, NW, Buchanan, Thomas A, Morken, Mario A, Lathrop, G.M., Min, Josine L, Pellikka, Niina, Karen Kapur, Michael Boehnke, Gianluca Usala, Spector, T.D., Groves, C.J. (Christopher), Scott, LJ, Wilson, JF, Perry, John RB, Kvaloy, K., Knowles, J.W. (Joshua), Zillikens, M., Jansson, John-Olov, Holmes, Christopher C., Absher, D., Kao, W. H. Linda, Johnson, T. (Toby), Wilson, J.F. (James), Zillikens, MC, White, C.C., Meitinger, T. (Thomas), Weedon, M., Cooper, M.N. (Matthew), Erdos, Michael R, Boeing, H., Froguel, P., Peter Kovacs, Jorgensen, Torben, Wheeler, E. (Eleanor), Timpson, N.J., Robertson, N.R. (Neil), Froguel, P, Fox, Caroline S, Syvanen, AC, Kvaloy, Kirsti, Uda, M., Freimer, Nelson B, Rivadeneira Ramirez, F. (Fernando), Lantieri, Olivier, McKnight, Barbara, Pedersen, Oluf, Harris, Tamara B, Peters, M.J., Kettunen, Johannes, Campbell, H. (Harry), Witte, Daniel R, Wheeler, E., Caulfield, M. (Mark), Boehnke, M, Sanna, S, Isomaa, B., Joel N Hirschhorn, Peltonen, L, Keri L Monda, Eestrada, K. (Karol), van Wingerden, S, Hu, F.B., Boeing, H. (Heiner), Kao, W.H.L., Cooper, Matthew N, Borecki, Ingrid B., Stark, K. (Klaus), Peden, J. (John), Robert C Kaplan, Purcell, S., Swift, A.J., Leitzmann, Michael F, Wallaschofski, H., Pellikka, N., Schadt, EE, Isomaa, B. (Bo), Vedantam, Sailaja, Nelis, M. (Mari), Parker, A.N. (Alex), Eiriksdottir, G, Perry, John R. B., Ebrahim, S., Hveem, K., Illig, T. (Thomas), Min, JL, Zillikens, M.C. (Carola), Tamara B Harris, Sovio, U, Vjekoslav Krzelj, Khaw, K-T. (Kay-Tee), Wichmann, H-Erich, Aspelund, T. (Thor), White, Charles C, Schlessinger, D., Timothy D Spector, Isomaa, B, Narisu, N., Silander, K. (Kaisa), Winkler, T.W. (Thomas), Platou, C.G.P., White, C., Seppo Koskinen, Dei, Mariano, Chines, P.S., van Duijn, CM, Schadt, Eric E., Dei, M. (Mariano), Vandenput, Liesbeth, Nicholas John Timpson, White, CC, Chasman, Daniel I, Kolcic, I., Havulinna, A.S., Johnson, T., Salomaa, V, Jian Yang, Yang, Jian, Steinthorsdottir, V, Pedersen, O. (Oluf), Winkler, Thomas W., Kaplan, Lee M., Hveem, K. (Kristian), Goddard, Michael E, Moffatt, M.F. (Miriam), Shuldiner, A.R., Strawbridge, Rona J., Jula, A. (Antti), Workalemahu, T, Zondervan, KT, Hassanali, N. (Neelam), Soranzo, N. (Nicole), Platou, C.G., Nyholt, Dale R, Syvanen, Ann-Christine, Kaplan, R.C. (Robert), Uda, Manuela, Isomaa, Bo, Prokopenko, Inga, Parker, Alex N., Francis S Collins, Peters, M.J. (Marjolein), Teslovich, Tanya M, Bergmann, Sven, Amy J Swift, Lawlor, Debbie A., Launer, Lenore J., Bergmann, S.M. (Sven), Loos, R.J.F. (Ruth), Neville, MJ, Wareham, N.J. (Nick), Nieminen, Markku S, Hunter, David J, Alavere, H. (Helene), Chines, Peter S, Vatin, V., Esko, T, Almgren, Peter,, Nicholas J Wareham, Stefansson, K. (Kari), Volpato, Claudia B, Bennett, A.J. (Amanda), Bornstein, S.R. (Stefan), Uitterlinden, A, Heiner Boeing, Karl-Heinz Herzig, Rissanen, A., Laitinen, J, North, K.E, Paavo Zitting, Absher, Devin, Molony, C. (Cliona), Nicholson, G. (Ggeorge), Schwarz, P.E., Pellikka, N. (Niina), Mika Kähönen, H-Erich Wichmann, Tthorleifsson, G. (Ggudmar), Eerdos, M.R. (Micheal), Kraja, A.T., Kilpeläinen, Tuomas O, Brenda W Penninx, O'Cconnell, J.R. (Jeffrey), Wingerden, S. van, Cupples, LA, Penninx, Brenda W., Zgaga, L., Beckmann, J.S., Lettre, G. (Guillaume), Bruce M Psaty, Palmer, C. (Cameron), Jula, A, Penninx, B.W., McCarthy, M.I., John F Peden, Morris, Andrew P., Polasek, O., Ong, Ken K., Hansen, T. (Torben), Koskinen, S., Uitterlinden, A., Claudia B Volpato, Collins, Francis S., Sinisalo, Juha, Weyant, R.J. (Robert), Niina Pellikka, Harris, TB, Allen, HL, Deloukas, Panos, Zondervan, K.T. (Krina), Harris, T., Wareham, Nicholas J., O'Connell, J.R., Laitinen, Jaana, Abecasis, GR, Oostra, B.A. (Ben), Speliotes, EK, Karpe, Fredrik, Zhao, J.H., Ludwig, B, Berndt, SI, Lantieri, O, Bouatia-Naji, N, Vitart, V, Liang, L. (Liming), MAGIC, Hayward, C, Rona J Strawbridge, Borecki, I.B. (Ingrid), Assimes, Themistocles L, Berndt, S., Gyllensten, U. (Ulf), Vedantam, S, Lina Zgaga, Strachan, DP, Speliotes, E., Glazer, N.L., Balkau, B. (Beverley), Luben, Robert N., Assimes, TL, Kettunen, J, Bornstein, Stefan R., Moffatt, Miriam F., Themistocles L Assimes, Schadt, Eric E, Spector, TD, Igor Rudan, Smit, JH, McCarthy, Anne, Benjamin F Voight, Berndt, S.I., Nieminen, M.S., Quertermous, T. (Thomas), Hartikainen, A.L., Yang, J.A., Ommen, G.J. van, Jouke-Jan Hottenga, van Meurs, JB, Hveem, Kristian, Jørgensen, Torben, Henry Völzke, Hattersley, Andrew T., Volpato, C.B., Buchanan, T.A., Tönjes, A, Jousilahti, P., Geus, Eco J C, Peden, JF, Liang, L., Kaakinen, M, Uda, M. (Manuela), Lehtimäki, T, Strachan, David P, null null, Tammesoo, ML, Abecasis, G.R. (Gonçalo), Teder-Laving, M., Hassanali, N., Speliotes, Elizabeth K, Samani, Nilesh J., Platou, CGP, Campbell, H, Pichler, I. (Irene), Bouatia-Naji, Nabila, Chines, P.S. (Peter), Hofman, Bert, Kolcic, I, Eriksson, Johan G., Jousilahti, P. (Pekka), Kajantie, E., Hui, J. (Jennie), Nyholt, D.R. (Dale), Matthew N Cooper, Anne McCarthy, Feitosa, Mary F., Michael Stumvoll, Wood, A.R. (Andrew), Jorma Viikari, Gaget, S., Sinisalo, J. (Juha), Heid, IM, Day, IN, Kay-Tee Khaw, Dei, M., Teder-Laving, Maris, McCcarthy, A. (Anne), Heyo K Kroemer, Pouta, Anneli, Kraft, P, Khaw, K-T, Stark, K., Kao, W H Linda, Leena Kinnunen, Anke Tönjes, Surakka, I. (Ida), North, K.E. (Kari), Iribarren, C, Ridker, Paul M, Arnold, Alice M, Shah Ebrahim, Fu, M., Heid, I., Sven Bergmann, Johansson, A, Gudmar Thorleifsson, Lathrop, GM, Coin, L, Grallert, Harald, Peters, Marjolein J, Jarvelin, M-R, Workalemahu, T., Fu, Mao, Havulinna, Aki S, John P Beilby, Lawlor, DA, Patricia B Munroe, Mangino, Massimo, de Geus, E.J.C.; id_orcid, Lokki, M.L., Ohlsson, Claes,, Hicks, A.A. (Andrew), Irene Pichler, Lyle J Palmer, Ripatti, S. (Samuli), Wild, S.H., Gonneke Willemsen, Liang, LM, Christopher J Groves, Abecasis, Goncalo R., Albert Vernon Smith, Hassanali, Neelam, Hamsten, A. (Anders), Ferreira, T, James F Wilson, Midthjell, K., Stefansson, K., Eiriksdottir, G., van Meurs, J.B., Sspeliotes, E.K. (Eelizabeth), Markku S Nieminen, Alan F Wright, Johanna Kuusisto, Massimo Mangino, Caroline Hayward, Willemsen, G, Harris, Tamara B., Hunter, David J., Teder-Laving, M, Eesko, T. (Tõnu), Harry Campbell, Goddard, ME, Jousilahti, Pekka, Nemesh, J, Min, J. (Josine), Strachan, D.P., Launer, LJ (Lenore), Fisher, Eva, Cavalcanti-Proença, C., Peter Almgren, Uitterlinden, André; id_orcid, Surakka, I, Cooper, MN, Kahonen, Mika, Veronique Vitart, Rivadeneira, F., James, AL, Viikari, J, Rudan, Igor, Smith, George Davey, Beckmann, Jacques S., Luben, RN, Zitting, P., Ingrid B Borecki, Inês Barroso, Jansson, J.O., Ben-Shlomo, Yoav, Andrew R Wood, Jan H Smit, Neville, M.J. (Matthew), Kraft, P. (Peter), Weedon, Michael N, Sovio, U., Estrada, Karol, Johnson, Toby, Lawlor, Debbie A, Strawbridge, R.J. (Rona), Meitinger, T, Eeriksson, J.G. (Johan), Teslovich, T.M. (Tanya), Schwarz, Peter EH, Day, Ian NM, Thorsteinsdottir, U., Molony, Cliona, Swift, Amy J., Moffatt, Miriam F, Boomsma, DI, Bennett, Amanda J., Nemesh, James, Mohlke, KL, Ingelsson, E. (Erik), Cavalcanti-Proença, C, van Wingerden, Sophie, Monda, Keri L, Sarah H Wild, Philippe Froguel, Yang, J. (Joanna), Biffar, R. (Reiner), Grässler, J, Weedon, M.N. (Michael), Ridker, P.M. (Paul), Järvelin, M.R., Kutalik, Z., Psaty, BM, Hartikainen, A-L, Feitosa, M.F., Bonnycastle, Lori L., Willemsen, G., Tuomi, T, Liang, Liming, Kolcic, Ivana, Lindgren, C.M., Glazer, Nicole L, Bennett, AJ, Kinnunen, Leena, Leitzmann, Michael F., Jaakko Kaprio, Quertermous, T, Boomsma, D.I., Psaty, B.M., Ulla Sovio, Nieminen, Markku S., Hansen, Torben, McCarthy, A, Raitakari, O. (Olli), Sinisalo, J, Hofman, A, Sovio, Ulla, Geus, E.J.C., Witteman, Jacqueline C., Perry, John R B, Frayling, T.M., Welch, R.P. (Ryan), Pramstaller, Peter P, Rudan, I, Michael E Goddard, Charles C White, Narisu, N, Launer, LJ, Vitart, V., Nyholt, Dale R., Beilby, John P., Pedersen, O, Bonnycastle, L.L. (Lori), Witteman, J.C.M. (Jacqueline), Kapur, K, Day, INM, van Meurs, Joyce, Timpson, N.J. (Nicholas), Lango Allen, H, James, Alan L., Paré, G, O'Connell, Jeffrey R., Weyant, Robert J., Jian'an Luan, Vollenweider, P. (Peter), Krina T Zondervan, Purcell, S. (Shaun), Wendy L McArdle, Polasek, O, Min, Josine L., Nilesh J Samani, Gaget, S, Ohlsson, Claes, Luan, J.A., Kettunen, J., L Adrienne Cupples, Samuli Ripatti, Hamsten, Anders, Loos, Ruth JF, Boehnke, M., Kaplan, Robert C., Silander, K, Welch, Ryan, Lamina, C., Saramies, J., Teslovich, T.M., Arnold, A.M. (Alice), McCarthy, Mark I, Karpe, F, Parker, A.N., Surakka, I., Wlawrence, R. (Robert), Tonjes, A., Amin, N. (Najaf), White, C.C. (Charles), Arnold, A.M., Strawbridge, RJ, Mangino, M., Zgaga, Lina, Shamika Ketkar, Randall, Joshua C, Kuusisto, J, Bonnycastle, LL, Sanna, S., Nicole L Glazer, Silander, K., Ketkar, Shamika, Jorgensen, T, Torben Jørgensen, Loos, Ruth J F, Kutalik, Zoltan, Zillikens, M. Carola, Valle, Timo T., Qi, L. (Lu), Randall, J.C., Johansson, Asa, John-Olov Jansson, Almgren, P., Hofman, A., Robert J Weyant, Lu Qi, Marika Kaakinen, Launer, Lenore J, Anette P Gjesing, Watanabe, R.M., Vernon Smith, A, Stark, Klaus, Valgerdur Steinthorsdottir, Jarvelin, Marjo-Riitta, Cecilia M Lindgren, Wichmann, H-E, Voight, Benjamin F., Markku Laakso, Estrada, K, North, Kari E, Sandholt, C, Bergman, R.N., Almgren, Peter, Vedantam, S., Salomaa, Veikko, Bergman, Richard N., Ridderstrale, Martin, Collins, Francis S, Laakso, M, Groop, L.C., Ingelsson, Erik, Holmes, C. (Christopher), Freimer, N.B. (Nelson), Eleanor Wheeler, Andres Metspalu, Guillaume Lettre, Robertson, R., McCarthy, MI, Kao, WH Linda, Gyllensten, U., Leitzmann, M.F. (Michael), Pramstaller, P.P. (Peter Paul), Kähönen, M, Jørgensen, T. (Torben), Kulzer, Jennifer R., Liming Liang, Biffar, R, Ohlsson, C, Thomas Illig, Absher, D, Kaplan, L.M., Day, I.N.M. (Ian), Stringham, Heather M., Launer, L.J., Maris Teder-Laving, Andrew A Hicks, Chasman, Daniel I., Mark J Caulfield, Caulfield, M.J., Usala, G, Fernando Rivadeneira, Martin Ridderstråle, Debbie A Lawlor, Strawbridge, R.J., George Davey Smith, Sinisalo, J., Daniel R Witte, Paré, G. (Guillaume), Uitterlinden, Andre, Mangino, M, Daniel I Chasman, Almgren, P, Beilby, J.P. (John), Robertson, NR, Jansson, JO, Ohlsson, C. (Claes), Jouko Saramies, Loos, Ruth J. F., Schwarz, Peter E. H., Stringham, H.M. (Heather), Kovacs, P., Cavalcanti-Proenca, Christine, Fisher, E., Larry D Atwood, Neville, Matt J, Ida Surakka, Hunter, DJ, Lecoeur, C. (Cécile), Schadt, E.E., Loos, RJF, Munroe, Patricia B., Purcell, S, Havulinna, A.S. (Aki), Groves, C.J., Collins, F.S., Grässler, Jürgen, Estrada, K., Palmer, Lyle J, George Nicholson, Kraja, AT, Quertermous, Thomas, Gyllensten, Ulf, Morris, A.D. (Andrew), Perola, Markus, Rayner, N.W., Hottenga, JJ (Jouke Jan), Groop, Leif C +999 morecore +1 more sourceMetastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano +2 morewiley +1 more sourceLipase inhibition attenuates the acute inhibitory effects of oral fat on food intake in healthy subjects [PDF]
, 2003 The lipase inhibitor, orlistat, is used in the treatment of obesity and reduces fat absorption by about 30%. However, the mean weight loss induced by orlistat is less than expected for the degree of fat malabsorption.O'Donovan, D., Wishart, J., Horowitz, M., Feinle-Bisset, C. +3 morecore +1 more sourceComparing weight loss rates between males and females: a preliminary analysis
Journal of the International Society of Sports NutritionBackground Biological differences between males and females include variations in fat-free mass, resting metabolic rate, and hormone profiles. Males have more lean muscle and visceral fat, likely associated with differences in testosterone, while females Valentina Rodriguez Da Silva, Ryan Singh, Valeria V. Silva Ramirez, Daniel Arevalo, Eric T. Trexler, Landon Shannahan, John Solis, Samuel Blanke, Samuel Evers, Talon Westervelt, John Holtje, Bill I. Campbell +11 moredoaj +1 more sourceA novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz +9 morewiley +1 more sourceCirculating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong +6 morewiley +1 more sourceEpigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun +9 morewiley +1 more source
