Results 81 to 90 of about 535,411 (309)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Body fat free mass is associated with the serum metabolite profile in a population-based study. [PDF]

, 2012
To characterise the influence of the fat free mass on the metabolite profile in serum samples from participants of the population-based KORA (Cooperative Health Research in the Region of Augsburg) S4 study.
Döring, Angela, Wichmann, Heinz-Erich, Fabian J. Theis, Elisabeth Altmaier, Karsten Suhre (67967), Gieger, C., Christian Gieger, Christa Meisinger (39940), Döring, A., Krumsiek, J., Karsten Suhre, Gabi Kastenmüller (127487), Prehn, C., Linseisen Jakob, Römisch-Margl, Werner, Jan Krumsiek (127460), Jourdan, Carolin, Christian Gieger (87555), Theis, F.J., Wang-Sattler, R., Jan Krumsiek, Kastenmüller, Gabi, H.-Erich Wichmann (72009), Gieger Christian, Altmaier, E., Wichmann, H.-E., Angela Döring (64291), Illig, T., Fabian J Theis, Linseisen, J., Peters, Annette, Illig Thomas, Kastenmüller Gabi, Theis, Fabian J., Jakob Linseisen, Peters Annette, Altmaier, Elisabeth, Wichmann H.-Erich, Annette Peters (62601), Rui Wang-Sattler (36841), Carolin Jourdan (155791), Jerzy Adamski, Linseisen, Jakob, Römisch-Margl Werner, Angela Döring, Annette Peters, Wang-Sattler, Rui, Krumsiek, Jan, Theis Fabian J., Thomas Illig (44906), Petersen Ann-Kristin, Werner Römisch-Margl, Ann-Kristin Petersen (149959), Jakob Linseisen (123573), Werner Römisch-Margl (127480), Peters, A., Krumsiek Jan, Elisabeth Altmaier (155799), Illig, Thomas, Wang-Sattler Rui, Adamski, Jerzy, Thomas Illig, Cornelia Prehn, H-Erich Wichmann, Meisinger Christa, Christa Meisinger, Jourdan, C., Römisch-Margl, W., Jerzy Adamski (127482), Petersen, Ann-Kristin, Gabi Kastenmüller, Suhre Karsten, Fabian J. Theis (127485), Gieger, Christian, Suhre, K., Meisinger, C., Cornelia Prehn (137977), Ann-Kristin Petersen, Adamski Jerzy, Kastenmüller, G., Prehn, Cornelia, Jourdan Carolin, Rui Wang-Sattler, Petersen, A.-K., Rui Wang, Meisinger, Christa, Döring Angela, Prehn Cornelia, Adamski, J., Suhre, Karsten, Altmaier Elisabeth, Carolin Jourdan   +91 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Acute Effects of a Commercially Available Caffeinated and Caffeine-Free Thermogenic Dietary Supplement on Resting Energy Expenditure, Hunger, and Hemodynamic Responses

Nutraceuticals
There has been a rise in popularity of “stimulant-free” or caffeine-free fat loss supplements, but it is not well understood whether those fat loss supplements are effective at enhancing thermogenesis without caffeine’s influence.
Kworweinski Lafontant, Jacob Broeckel, Kara Phillips, Yasamian Alsayed, Wayne A. Ayers-Creech, Yuto Ohigashi, John Solis, Cassidy Bale, Arielle Parks, Scott Dankel, Bill I. Campbell   +10 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

High impact activity is related to lean but not to fat mass: findings from a population-based study in adolescents [PDF]

, 2012
Background: Objective measures of physical activity calibrated against energy expenditure may have limited utility in studying relationships with musculoskeletal phenotypes.
Rittweger, Jörn, Deere, Kevin, Tobias, Jonathan H, Davey Smith, George, Tobias, Jon, Sayers, Adrian   +5 more
core   +1 more source

Potential Biomarkers of Fat Loss as a Feature of Cancer Cachexia

Mediators of Inflammation, 2015
Fat loss is associated with shorter survival and reduced quality of life in cancer patients. Effective intervention for fat loss in cachexia requires identification of the condition using prognostic biomarkers for early detection and prevention of ...
Maryam Ebadi, Vera C. Mazurak
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Effect of diet with or without exercise on abdominal fat in postmenopausal women – a randomised trial

BMC Public Health, 2019
Background We assessed the effect of equivalent weight loss with or without exercise on (intra-) abdominal fat in postmenopausal women in the SHAPE-2 study.
Willemijn A. van Gemert, Petra H. Peeters, Anne M. May, Adriaan J. H. Doornbos, Sjoerd G. Elias, Job van der Palen, Wouter Veldhuis, Maaike Stapper, Jantine A. Schuit, Evelyn M. Monninkhof   +9 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source