CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu +10 more
wiley +1 more source
Innovations in the dairy chain: bio-economic analysis of novel breeding opportunities
In recent years, there has been a growing interest in the dairy sector to move from producing bulk dairy commodities towards producing specialized dairy products aimed at niche markets. Dairy farmers consider shifting from commodity milk to raw milk with
Demeter, R.M.
core
Contractile properties and magnetic resonance imaging-assessed fat replacement of muscles in myotonia congenita. [PDF]
Jacobsen LN +5 more
europepmc +1 more source
Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li +22 more
wiley +1 more source
G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
Effect of fat replacement in high internal phase emulsions constructed by high temperature saccharification of grafted proteins on gel properties and flavor profiles of sausages. [PDF]
Lu F, Chi Y, Chi Y.
europepmc +1 more source
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao +12 more
wiley +1 more source
A dietary interventional study moderating fat intake in Saudi subjects with metabolic disease [PDF]
The gut-derived bacteria, endotoxin (lipopolysaccharide), have been observed to be raised in patients with type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD) which appears to represent a source of diet induced inflammation exacerbating ...
Aldesi, Darh Assad D.
core
Optimize fat Replacers in food
BACKGROUND: Fat is obtained from plant and animal sources and exists in most nutritious products which affects their sensory properties. The growing trend of diseases such as high cholesterol, heart disease and obesity made the nutrition experts look for the alternative fat with lower-calorie.
openaire +1 more source

