Results 181 to 190 of about 1,940,158 (289)

Ovarian hormones and high-fat diet duration distinctively modulate hypothalamic chemokine profile. [PDF]

J Neuroendocrinol
Augusto AGB, Dos Santos GA, Cavalheiro IVS, Mantovan VS, Bergantini LS, Marin NP, Dos Santos Alves E, Velloso LA, Mendes NF.   +8 more
europepmc   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

Multi-Parametric MRI Approach at 3 T and 7 T for Assessing Skeletal Muscle Pathology in Myofibrillar Myopathies: A Pilot Study. [PDF]

J Cachexia Sarcopenia Muscle
Mathy CS, Gast LV, Holtzhausen C, Gerhalter T, Stuprich C, Türk M, Heiss R, Marty B, Laun FB, Wanschitz JV, Hametner S, Dörfler A, Uder M, Bäuerle T, Nagel AM, Schröder R.   +15 more
europepmc   +1 more source

Imaging‐Guided Live Single‐Cell Lipid Profiling of Leader and Follower Cells During Collective Migration of Triple‐Negative Breast Cancer Cells

Advanced Science, EarlyView.
Integrated single‐cell mass spectrometry reveals distinct lipidomic signatures that differentiate leader and follower phenotypes in migratory breast cancer cells. Phenotype‐specific alterations across various lipid classes, including fatty acids and phosphatidylcholines, underpin functional heterogeneity.
Xiaoyue Huang, Judit González Riera, Mai Nguyen, Jeremy Broekhuis, Sylvia E. Le Dévédec, Ahmed Ali, Thomas Hankemeier   +6 more
wiley   +1 more source

Longitudinal Assessment of Muscle Involvement in Late-Onset Pompe Disease Using Quantitative MRI: A Prospective Cohort Study. [PDF]

J Cachexia Sarcopenia Muscle
De Lorenzo A, Forsting J, Froeling M, Güttsches AK, Enax-Krumova E, Kleefeld F, Öztürk M, Knieling F, Vorgerd M, Rehmann R, Ruck T, Schlaffke L.   +11 more
europepmc   +1 more source

Effects of fat replacement and fibre addition on the texture, sensory acceptance and structure of sucrose‐free chocolate

, 2015
Natália V. Rezende, M. Benassi, F. Z. Vissotto, P. Augusto, M. Grossmann   +4 more
semanticscholar   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Essentials for optimizing outcomes in oncoplastic breast reconstruction. [PDF]

Gland Surg
Morris M, Ghosh K, Hanson SE.
europepmc   +1 more source

Wavelength‐Dependent Photobiomodulation Regulates Macrophage Polarization via Mitochondrial Dynamics and Metabolic Reprogramming

Advanced Science, EarlyView.
Light wavelength encodes distinct macrophage fates through mitochondrial and metabolic remodeling. Red 625 nm irradiation induces glycolysis, mitochondrial fission, and M1 polarization, whereas near‐infrared 850 nm irradiation promotes fatty acid oxidation, mitochondrial fusion, and M2 polarization.
Qiusheng Shi, Hao Jia, Jianfei Dong, Linhao Li, Jingqi Cao, Xun Chen, Zhenzhen Jia, Jing Na, Zhijie Yang, Xinyuan Chen, Yubo Fan, Shuhua Yue, Lisha Zheng   +12 more
wiley   +1 more source