Results 1 to 10 of about 401,489 (268)

Engineering mouse cell fate controller by rational design

Nature Communications
Cell fate is likely regulated by a common machinery, while components of this machine remain to be identified. Here we report the design and testing of engineered cell fate controller NanogBiD, fusing BiD or BRG1 interacting domain of SS18 with Nanog ...
Tao Huang, Dong Liu, Xiaomin Wang, Junqi Kuang, Manqi Wu, Beibei Wang, Zechuan Liang, Yixin Fan, Bo Chen, Zhaoyi Ma, Yu Fu, Wenhui Zhang, Jin Ming, Yue Qin, Chengchen Zhao, Bo Wang, Duanqing Pei   +16 more
doaj   +1 more source

Vitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics

Stem Cells International, 2017
Transcription factors and signaling molecules are well-known regulators of stem cell identity and behavior; however, increasing evidence indicates that environmental cues contribute to this complex network of stimuli, acting as crucial determinants of ...
Cristina D'Aniello, Federica Cermola, Eduardo Jorge Patriarca, Gabriella Minchiotti   +3 more
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Ki67 Immunofluorescence on Bovine Cell Lines

Bio-Protocol, 2013
This is a rapid protocol to test the effects of drugs treatment on bovine cell replication using Ki67 staining. Ki67 is associated with cell proliferation and is present during all active phases of the cell cycle (G1, S, G2, and mitosis), but is absent ...
Justine Marsolier, Souhila Medjkane, Martine Perichon, Jonathan Weitzman   +3 more
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ESTUDIO Y CARACTERIZACIÓN DE MODOS NORMALES EN NEUMÁTICOS PARA VEHÍCULOS DE PASAJEROS

Anales (Asociación Física Argentina), 2014
Se analizaron las frecuencias naturales de vibración mediante análisis modal con martillo instrumentado para dos neumáticos radiales de automóvil de distintas medidas.
M E Dalmau, L F Jaureguizahar, J Kuster, A J Marzocca   +3 more
doaj  

Theileria parasites sequester host eIF5A to escape elimination by host-mediated autophagy

Nature Communications
Intracellular pathogens develop elaborate mechanisms to survive within the hostile environments of host cells. Theileria parasites infect bovine leukocytes and cause devastating diseases in cattle in developing countries. Theileria spp.
Marie Villares, Nelly Lourenço, Ivan Ktorza, Jérémy Berthelet, Aristeidis Panagiotou, Aurélie Richard, Angélique Amo, Yulianna Koziy, Souhila Medjkane, Sergio Valente, Rossella Fioravanti, Catherine Pioche-Durieu, Laurent Lignière, Guillaume Chevreux, Antonello Mai, Jonathan B. Weitzman   +15 more
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Self-assembled chamber-like cardiac organoids for modeling cardiac chamber formation and cardiotoxicity assessment

Nature Communications
The human heart remains a central focus of biomedical research, yet capturing early chamber morphogenesis in vitro with structural and functional fidelity remains challenging.
Xinle Zou, Fanwen Wang, Huilin Zheng, Xianzhuang Liu, Tianci Kong, Rui Jiang, Yingying Guo, Yu Liang, Hanqing Zhao, Bo Wang, Duanqing Pei   +10 more
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Breaking the link between morphology and potency for mESCs

Cell & Bioscience
Background In stem cell biology, a long-held structure–function relationship is the domed colony morphology and naïve pluripotency for mouse or human pluripotent stem cells. This link has provided a convenient way to recognize bona fide naïve pluripotent
Yixin Fan, Xiaomin Wang, Ziwei Zhai, Tao Huang, Wei Li, Zechuan Liang, Zhaoyi Ma, Yu Fu, Pengli Li, Junqi Kuang, Duanqing Pei   +10 more
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Proteomic profiling of UV damage repair patches uncovers histone chaperones with central functions in chromatin repair

Nature Communications
DNA damage compromises not only genome stability but also chromatin integrity, which plays a central role in controlling cell identity. Chromatin repair entails the deposition of new histones at sites of DNA damage.
Alexandre Plessier, Audrey Chansard, Eliane Petit, Julia Novion Ducassou, Yohann Couté, Sophie E. Polo   +5 more
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X chromosome inactivation in mammals: general principles and species-specific considerations

EMBO Reports
X chromosome inactivation (XCI) is a mammalian dosage compensation mechanism that ensures balanced expression of X-linked genes between males and females. Research using rodent models has led to major discoveries regarding XCI mechanisms and dynamics, in
Charbel Alfeghaly, Claire Rougeulle
doaj   +1 more source

An Improved m6A-ELISA for Quantifying N6-methyladenosine in Poly(A)-purified mRNAs

Bio-Protocol
N6-methyladenosine (m6A) is an abundant internal mRNA modification with roles in regulating cellular and organismal physiology, including development, differentiation, and disease. The deposition of m6A is highly regulated, with various m6A levels across
Wei Chan, Waleed Albihlal, Folkert Van Werven   +2 more
doaj   +1 more source