Results 21 to 30 of about 1,264,513 (255)

Quantitative microscopy of the Drosophila ovary shows multiple niche signals specify progenitor cell fate. [PDF]

, 2017
Adult stem cells commonly give rise to transit-amplifying progenitors, whose progeny differentiate into distinct cell types. It is unclear if stem cell niche signals coordinate fate decisions within the progenitor pool.
Burrous, Haley, Dai, Wei, Kenney, Thomas, Montell, Denise J, Peterson, Amy   +4 more
core   +2 more sources

Ultimate Fate of Constrained Voters [PDF]

, 2004
We determine the ultimate fate of individual opinions in a socially-interacting population of leftists, centrists, and rightists. In an elemental interaction between agents, a centrist and a leftist can become both centrists or both become leftists with ...
Redner, S., Vazquez, F.
core   +3 more sources

iPSC-derived trimodal T cells engineered with CAR, TCR, and hnCD16 modalities can overcome antigen escape in heterogeneous tumors

Cell Reports Medicine
Summary: Although chimeric antigen receptor (CAR) T cells have demonstrated therapeutic activity in hematopoietic malignancies, tumor heterogeneity has impeded the efficacy of CAR T cells and their extension into successful solid tumor treatment.
Bi-Huei Yang, Alma Gutierrez, Angela Liao, Soheila Shirinbak, Bjoern Gaertner, Mochtar Pribadi, Hui-Yi Chu, Pei-Fang Tsai, Yu-Sheng Eason Lin, David Gonzalez, Wen-I Yeh, Chia-Wei Chang, Ryan Bjordahl, Tom Lee, Martin Hosking, Eigen Peralta, Bahram Valamehr   +16 more
doaj   +1 more source

The fate of pentagastrin [PDF]

Gut, 1971
Pentagastrin is rapidly removed from the circulation of the dog. It is excreted by the liver into the bile, largely in an inactivated form. Preliminary results indicate that it meets the same fate in man.
B H, Stagg, J M, Temperley, J H, Wyllie
openaire   +2 more sources

A chemical approach facilitates CRISPRa-only human iPSC generation and minimizes the number of targeted loci required

Future Science OA
Aim: We explored the generation of human induced pluripotent stem cells (iPSCs) solely through the transcriptional activation of endogenous genes by CRISPR activation (CRISPRa). Methods: Minimal number of human-specific guide RNAs targeting a limited set
Ramzey Abujarour, Jason Dinella, Mochtar Pribadi, Lauren K Fong, Matthew Denholtz, Alma Gutierrez, Matt Haynes, Enaaya Mahmood, Tom T Lee, Sheng Ding, Bahram Valamehr   +10 more
doaj   +1 more source

Capturing Transitional Pluripotency through Proline Metabolism

Cells, 2022
In this paper, we summarize the current knowledge of the role of proline metabolism in the control of the identity of Embryonic Stem Cells (ESCs). An imbalance in proline metabolism shifts mouse ESCs toward a stable naïve-to-primed intermediate state of ...
Gabriella Minchiotti, Cristina D’Aniello, Annalisa Fico, Dario De Cesare, Eduardo Jorge Patriarca   +4 more
doaj   +1 more source

Nietzsche and Amor Fati [PDF]

, 2009
This paper identifies two central paradoxes threatening the notion of amor fati [love of fate]: it requires us to love a potentially repellent object (as fate entails significant negativity for us) and this, in the knowledge that our love will not modify
Andersen, Aristotle, Austin, Benvéniste, Clark, Davidson, Eberhard, Frede, Gardner, Gilson, Gould, Hatab, Homer, Kant, Katz, Kemmer, Leibniz, Leiter, Llewelyn, Long, Löwith, Magnus, Marcus Aurelius, Mele, Mele, Nehamas, Nussbaum, Nygren, Owen, Pascal, Pears, Plato, Plato, Reginster, Roberts, Sartre, Sells, Simmel, Singer, Smyth, Soble, Soll, Stambaugh, Strawson, Teresa of Avila, Vernant, Vlastos, Yovel   +47 more
core   +1 more source

The Effects of Stress Mindset Interventions on University Students\u27 Health and Functioning [PDF]

, 2019
In modern society, the overwhelming cultural narrative proclaims that stress is detrimental to health and should be limited and avoided at all costs.
Fate, Abigail
core   +1 more source

Control of Arabidopsis apical-basal embryo polarity by antagonistic transcription factors. [PDF]

, 2010
Plants, similarly to animals, form polarized axes during embryogenesis on which cell differentiation and organ patterning programs are orchestrated. During Arabidopsis embryogenesis, establishment of the shoot and root stem cell populations occurs at ...
Long, Jeff A, Smith, Zachery R
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source