Results 11 to 20 of about 401,489 (268)
Nature Communications, 2022 The use of chimeric antigen receptor modified immune cell therapeutics has improved the treatment of a range of tumours. Here the authors explore a dual-target iPSC-derived NK cell product as a potential therapeutic for the treatment of multiple myeloma.
Frank Cichocki +22 more
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iScience, 2023 Summary: The major lysine methyltransferase (KMT) Setdb1 is essential for self-renewal and viability of mouse embryonic stem cells (mESCs). Setdb1 was primarily known to methylate the lysine 9 of histone 3 (H3K9) in the nucleus, where it regulates ...
Roberta Rapone +7 more
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Frontiers in Endocrinology, 2022 Pancreatic beta cell response to glucose is critical for the maintenance of normoglycemia. A strong transcriptional response was classically described in rodent models but, interestingly, not in human cells.
Manuel Bulfoni +8 more
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Journal of Experimental Medicine, 1921 Although the count of circulating lymphocytes in the blood stream remains constant, more lymphocytes enter the blood from the thoracic duct during 24 hours than are present in the blood at any one time. This excess of lymphocytes is not destroyed in the blood stream. The cells migrate from the blood vessels into the mucous membranes and through them to
C H, Bunting, J, Huston
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Dynamic methylation of histone H3K18 in differentiating Theileria parasites
Nature Communications, 2021 Post-translational modifications (PTM) of histones are important for epigenetic regulation in mammals. Here, Cheeseman et al. report dynamic changes in H3K18 PTM during the differentiation stages of Theileria parasites and they identify a SET-domain ...
Kevin Cheeseman +9 more
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Costumes and cinema: a didactic experience in the academic education of fashion designers
Projetica, 2018 This paper discusses the costumes in movies and their applicability in the academic education of fashion designers. The objectives are to understand the costumes as elements of the movie narrative and to discuss a proposal for the analysis of movie ...
Janote Pires Marques +1 more
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Identification of a dinucleotide signature that discriminates coding from non-coding long RNAs
Frontiers in Genetics, 2014 To date, the main criterion by which long ncRNAs (lncRNAs) are discriminated from mRNAs is based on the capacity of the transcripts to encode a protein. However, it becomes important to identify non-ORF-based sequence characteristics that can be used to ...
Damien eUlveling +3 more
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Generation of skeletal muscle cells from pluripotent stem cells: advances and challenges
Frontiers in Cell and Developmental Biology, 2015 Human pluripotent stem cells (hPSCs) possess unlimited proliferative potential while maintaining the ability to differentiate into any cell type including skeletal muscle cells (SMCs). hPSCs are amenable to genetic editing and can be derived from patient
Ramzey eAbujarour, Bahram eValamehr
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Single-cell Visualization of Chromosome Transcriptional Territories by RNA-paint
Bio-Protocol, 2016 We developed a FISH-based method to directly assess chromosome-wide transcriptional activity, thereby enabling the visualization of the actively transcribed fraction of a chromosome at the single-cell level.
Céline Vallot, Claire Rougeulle
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Nature Communications, 2021 How gene expression reactivation is promoted following DNA damage is not yet clear. Here, the authors identify a role for the human histone chaperone complex HIRA in transcription restart following UV damage independently of its function in new H3.3 ...
Déborah Bouvier +5 more
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