Results 11 to 20 of about 1,264,513 (255)

Identification of a dinucleotide signature that discriminates coding from non-coding long RNAs

open access: yesFrontiers in Genetics, 2014
To date, the main criterion by which long ncRNAs (lncRNAs) are discriminated from mRNAs is based on the capacity of the transcripts to encode a protein. However, it becomes important to identify non-ORF-based sequence characteristics that can be used to ...
Damien eUlveling   +3 more
doaj   +1 more source

The Fate of Fusions [PDF]

open access: yesCells, 2018
The concept of leukocyte-tumor cell fusion as a significant driver of cancer progression has been around a long time, and has garnered growing support over the last several years. The underlying idea seems quite simple and attractive: Fusion of tumor cells (with their inherent genetic instability) with leukocytes, particularly macrophages, could ...
openaire   +3 more sources

Generation of skeletal muscle cells from pluripotent stem cells: advances and challenges

open access: yesFrontiers in Cell and Developmental Biology, 2015
Human pluripotent stem cells (hPSCs) possess unlimited proliferative potential while maintaining the ability to differentiate into any cell type including skeletal muscle cells (SMCs). hPSCs are amenable to genetic editing and can be derived from patient
Ramzey eAbujarour, Bahram eValamehr
doaj   +1 more source

Free Will Pessimism [PDF]

open access: yes, 2017
The immediate aim of this paper is to articulate the essential features of an alternative compatibilist position, one that is responsive to sources of resistance to the compatibilist program based on considerations of fate and luck.
Russell, Paul
core   +1 more source

Single-cell Visualization of Chromosome Transcriptional Territories by RNA-paint

open access: yesBio-Protocol, 2016
We developed a FISH-based method to directly assess chromosome-wide transcriptional activity, thereby enabling the visualization of the actively transcribed fraction of a chromosome at the single-cell level.
Céline Vallot, Claire Rougeulle
doaj   +1 more source

A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans

open access: yesNature Communications, 2019
XACT is a primate-specific TE-derived lncRNA that coats active X chromosomes in pluripotent cells and may contribute to species-specific regulation of X chromosome inactivation.
Miguel Casanova   +7 more
doaj   +1 more source

Imaging the response to DNA damage in heterochromatin domains reveals core principles of heterochromatin maintenance

open access: yesNature Communications, 2021
The heterochromatin compartment is key for genome stability and cell fate transitions. Here, by tracking the heterochromatin response to UV damage in real time, the authors reveal how heterochromatin features are preserved following a genotoxic stress ...
Anna Fortuny   +6 more
doaj   +1 more source

LABOR EMPLOYMENT OPPORTUNITIES IN COFFEE PRODUCTION IN SOUTHERN LAO PEOPLE’S DEMOCRATIC REPUBLIC

open access: yesJournal of Asian Rural Studies, 2018
General debate on the issue of labor employment is related to employment opportunity, pattern of labor employment, the contribution to labor employment, and the impact of labor employment on livelihoods. This paper examines labor employment opportunities
Dexanourath Seneduangdeth   +4 more
doaj   +1 more source

Deciphering tissue structure and function using spatial transcriptomics

open access: yesCommunications Biology, 2022
Walker et al. review methods used to analyse spatial transcriptomics data and discuss open questions and areas of future development.
Benjamin L. Walker   +4 more
doaj   +1 more source

The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis [PDF]

open access: yes, 2019
Post-transcriptional mechanisms have the potential to influence complex changes in gene expression, yet their role in cell fate transitions remains largely unexplored.
Aigner, S.   +21 more
core   +3 more sources

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