Results 21 to 30 of about 1,253,544 (212)

A chemical approach facilitates CRISPRa-only human iPSC generation and minimizes the number of targeted loci required

Future Science OA
Aim: We explored the generation of human induced pluripotent stem cells (iPSCs) solely through the transcriptional activation of endogenous genes by CRISPR activation (CRISPRa). Methods: Minimal number of human-specific guide RNAs targeting a limited set
Ramzey Abujarour, Jason Dinella, Mochtar Pribadi, Lauren K Fong, Matthew Denholtz, Alma Gutierrez, Matt Haynes, Enaaya Mahmood, Tom T Lee, Sheng Ding, Bahram Valamehr   +10 more
doaj   +1 more source

iPSC-derived trimodal T cells engineered with CAR, TCR, and hnCD16 modalities can overcome antigen escape in heterogeneous tumors

Cell Reports Medicine
Summary: Although chimeric antigen receptor (CAR) T cells have demonstrated therapeutic activity in hematopoietic malignancies, tumor heterogeneity has impeded the efficacy of CAR T cells and their extension into successful solid tumor treatment.
Bi-Huei Yang, Alma Gutierrez, Angela Liao, Soheila Shirinbak, Bjoern Gaertner, Mochtar Pribadi, Hui-Yi Chu, Pei-Fang Tsai, Yu-Sheng Eason Lin, David Gonzalez, Wen-I Yeh, Chia-Wei Chang, Ryan Bjordahl, Tom Lee, Martin Hosking, Eigen Peralta, Bahram Valamehr   +16 more
doaj   +1 more source

Capturing Transitional Pluripotency through Proline Metabolism

Cells, 2022
In this paper, we summarize the current knowledge of the role of proline metabolism in the control of the identity of Embryonic Stem Cells (ESCs). An imbalance in proline metabolism shifts mouse ESCs toward a stable naïve-to-primed intermediate state of ...
Gabriella Minchiotti, Cristina D’Aniello, Annalisa Fico, Dario De Cesare, Eduardo Jorge Patriarca   +4 more
doaj   +1 more source

Histone Variants: Guardians of Genome Integrity

Cells, 2020
Chromatin integrity is key for cell homeostasis and for preventing pathological development. Alterations in core chromatin components, histone proteins, recently came into the spotlight through the discovery of their driving role in cancer.
Juliette Ferrand, Beatrice Rondinelli, Sophie E. Polo   +2 more
doaj   +1 more source

The Effects of Stress Mindset Interventions on University Students\u27 Health and Functioning [PDF]

, 2019
In modern society, the overwhelming cultural narrative proclaims that stress is detrimental to health and should be limited and avoided at all costs.
Fate, Abigail
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The Bibliothèque raisonnée Review of Volume 3 of the Treatise: Authorship, Text, and Translation [PDF]

, 2006
The review of volume 3 of Hume’s Treatise, a review that appeared in the Bibliothèque raisonnée in the spring of 1741, was the first published responseto Hume’s ethical theory.
Norton, David Fate, Perinetti, Dario
core  

The Fate of R-Parity

, 2010
The possible origin of the R-parity violating interactions in the minimal supersymmetric standard model and its connection to the radiative symmetry breaking mechanism (RSBM) is investigated.
Perez, Pavel Fileviez, Spinner, Sogee
core   +1 more source

Nietzsche and Amor Fati [PDF]

, 2009
This paper identifies two central paradoxes threatening the notion of amor fati [love of fate]: it requires us to love a potentially repellent object (as fate entails significant negativity for us) and this, in the knowledge that our love will not modify
Andersen, Aristotle, Austin, Benvéniste, Clark, Davidson, Eberhard, Frede, Gardner, Gilson, Gould, Hatab, Homer, Kant, Katz, Kemmer, Leibniz, Leiter, Llewelyn, Long, Löwith, Magnus, Marcus Aurelius, Mele, Mele, Nehamas, Nussbaum, Nygren, Owen, Pascal, Pears, Plato, Plato, Reginster, Roberts, Sartre, Sells, Simmel, Singer, Smyth, Soble, Soll, Stambaugh, Strawson, Teresa of Avila, Vernant, Vlastos, Yovel   +47 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source