Results 111 to 120 of about 149 (148)

High Fat Low Carbohydrate Diet Is Linked to CNS Autoimmunity Protection

Advanced Science, EarlyView.
Mapping global epidemiological data to macronutrient supply reveals high carbohydrate, in contrast to high fat supply, associates with increased multiple sclerosis (MS) prevalence and incidence. This is confirmed in a mouse MS model, experimental autoimmune encephalomyelitis (EAE), using isocaloric diets: a high carbohydrate diet aggravates, a high ...
Duan Ni, Jian Tan, Julen Reyes, Alistair M Senior, Caitlin Andrews, Jemma Taitz, Camille Potier‐Villette, Claire Wishart, Alanna Spiteri, Laura Piccio, Nicholas Jonathan Cole King, Romain Barrès, David Raubenheimer, Stephen James Simpson, Ralph Nanan, Laurence Macia   +15 more
wiley   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Histone Lactylation Antagonizes Senescence and Skeletal Muscle Aging by Modulating Aging‐Related Pathways

Advanced Science, EarlyView.
This study reveals histone lactylation as a metabolic‐epigenetic regulator countering cellular senescence and skeletal muscle aging. Reduced lactylation impairs cell cycle, DNA repair and proteostasis pathways, while exercise restores glycolytic activity and lactylation levels, preserving muscle function.
Fanju Meng, Jianuo He, Xuebin Zhang, Wencong Lyu, Ran Wei, Shiyi Wang, Zhehao Du, Haochen Wang, Jinlong Bi, Xueyang Hua, Chao Zhang, Yiting Guan, Guoliang Lyu, Xiao‐Li Tian, Lijun Zhang, Wenbing Xie, Wei Tao   +16 more
wiley   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

Advanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong, Pei Li, Yi Jiang, Zhihan Wang, Shihui Fu, Hebin Che, Meng Liu, Xiaojing Zhao, Chunlei Liu, Chenghui Zhao, Qin Zhong, Chongyou Rao, Siwei Wang, Suyuan Liu, Dayu Hu, Dongjin Wang, Juntao Gao, Kai Guo, Xinwang Liu, En Zhu, Kunlun He   +20 more
wiley   +1 more source

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ChemInform Abstract: Fatty Acids, Fatty Acid Analogues and Their Derivatives

ChemInform, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Marcel S. F. Lie Ken Jie, M. K. Pasha, M. S. K. Syed‐Rahmatullah   +2 more
openaire   +2 more sources

Fatty acids and glaucoma

Acta Ophthalmologica, 2014
AbstractRetinal cell membranes are known to be rich in ether‐linked phospholipids also termed as “plasmalogens”. Although their functions remain enigmatic, plasmalogens are considered as reservoirs of polyunsaturated fatty acids (PUFAs). These PUFAs were shown to be released from plasmalogens by specific enzymes under specific conditions in order to ...
Acar, Niyazi, Bron, Alain, Creuzot Garcher, Catherine, Brétillon, Lionel   +3 more
openaire   +4 more sources

Fatty Acids: Fatty Acids

2016
Fatty acids (FAs) are long hydrocarbon chain molecules with a terminal carboxylate group, originating from the organism or food. Their nomenclature, structure, and properties depend on the length of hydrocarbon chain, degree of unsaturation, and position of double bond(s).
Petrović, Snježana, Arsić, Aleksandra
openaire   +2 more sources

Partition of fatty acids and fluorescent fatty acids into membranes

Biochemistry, 1984
We have measured the membrane/water partition of free fatty acids, of a fluorescent analogue, and of chlorpromazine into plasma membranes from lymphoma, platelets, red cells, and liposomes of egg phosphatidylcholine. Three different methods were used: hygroscopic desorption [ Conrad , M.J., & Singer, S.J. (1979) Proc. Natl. Acad. Sci. U.S.A.
W.J. Pjura, Morris J. Karnovsky, Alan M. Kleinfeld   +2 more
openaire   +3 more sources

Fatty acids and Schizophrenia

Lipids, 1996
AbstractIn a controlled study of red cell membrane fatty acids in patients with schizophrenia, substantial depletions of fatty acids from both the n‐6 and n‐3 series were demonstrated. Arachidonic acid and docosahexaenoic acid were particularly depleted.
Malcolm Peet, Jonathan D. E. Laugharne, Jan E. Mellor   +2 more
openaire   +3 more sources

The Fatty Acids [PDF]

Nature, 1961
Fatty Acids Their Chemistry, Properties, Production, and Uses, Part 1. Edited by K. S. Markley. Second completely revised and augmented edition. (Fats and Oils: a Series of Monographs on the Chemistry and Technology of Fats, Oils, and Related Subjects.) Pp. ix + 714. (New York: Interscience Publishers, Inc.; London: Interscience Publishers, Ltd., 1960.)
openaire   +1 more source