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Frontiers in Genetics, 2022 Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent cancer in humans globally. In addition to smoking and drinking, genetic and epigenetic changes also play a big role in how HNSCC starts and grows.
Xiaojing Wang +7 more
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Fatty Acid Metabolism Reprogramming in Advanced Prostate Cancer
Metabolites, 2021 Prostate cancer (PCa) is a carcinoma in which fatty acids are abundant. Fatty acid metabolism is rewired during PCa development. Although PCa can be treated with hormone therapy, after prolonged treatment, castration-resistant prostate cancer can develop
Huan Xu +6 more
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Maternal Fatty Acid Metabolism in Pregnancy and Its Consequences in the Feto-Placental Development
Frontiers in Physiology, 2022 During pregnancy, maternal plasma fatty acids are critically required for cell growth and development, cell signaling, and the development of critical structural and functional aspects of the feto-placental unit. In addition, the fatty acids modulate the
Asim K. Duttaroy, Sanjay Basak
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Key Molecules of Fatty Acid Metabolism in Gastric Cancer
Biomolecules, 2022 Fatty acid metabolism is closely linked to the progression of gastric cancer (GC), a very aggressive and life-threatening tumor. This study examines linked molecules, such as Sterol Regulatory Element-Binding Protein 1 (SREBP1), ATP Citrate Lyase (ACLY),
Chunlei Li +4 more
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The diversity and breadth of cancer cell fatty acid metabolism
Cancer & Metabolism, 2021 Tumor cellular metabolism exhibits distinguishing features that collectively enhance biomass synthesis while maintaining redox balance and cellular homeostasis.
Shilpa R. Nagarajan +2 more
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Fatty Acid Metabolism and Idiopathic Pulmonary Fibrosis
Frontiers in Physiology, 2022 Fatty acid metabolism, including the de novo synthesis, uptake, oxidation, and derivation of fatty acids, plays several important roles at cellular and organ levels.
Jing Geng +5 more
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Cellular Fatty Acid Metabolism and Cancer [PDF]
Cell Metabolism, 2013 Cancer cells often have characteristic changes in metabolism. Cellular proliferation, a common feature of all cancers, requires fatty acids for synthesis of membranes and signaling molecules. Here, we provide a view of cancer cell metabolism from a lipid perspective, and we summarize evidence that limiting fatty acid availability can control cancer ...
Almut Schulze +4 more
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Epigenetic-Transcriptional Regulation of Fatty Acid Metabolism and Its Alterations in Leukaemia
Frontiers in Genetics, 2018 In recent years fatty acid metabolism has gained greater attention in haematologic cancers such as acute myeloid leukaemia. The oxidation of fatty acids provides fuel in the form of ATP and NADH, while fatty acid synthesis provides building blocks for ...
Michael Maher +4 more
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Exploring fatty acid metabolism in Alzheimer’s disease: the key role of CPT1A [PDF]
Scientific ReportsAlzheimer’s disease (AD) is a severe neurodegenerative disease, and the most common type of dementia, with symptoms of progressive cognitive dysfunction and behavioral impairment.
Yanxiu Ju +3 more
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Analysis of fatty acid metabolism in prostate cancer and discovery of a new programmed cell death-associated luminal cell subpopulation [PDF]
Discover OncologyIntroduction This study focuses on the role of fatty acid metabolism in prostate cancer, particularly in oncogenic luminal cells associated with programmed cell death under the influence of metabolic reprogramming.
Yan Zeng, Zhaolin Jiang
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