Results 51 to 60 of about 1,111,197 (376)

Clinical heterogeneity in a family with flail arm syndrome and review of hnRNPA1‐related spectrum

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1910-1917, December 2022., 2022
Abstract Objective Flail arm syndrome (FAS) is one of the atypical subtypes of amyotrophic lateral sclerosis (ALS). Mutations in hnRNPA1 encoding heterogeneous nuclear ribonucleoprotein (hnRNP) A1 are a rare genetic cause of ALS. Herein, marked clinical heterogeneity of FAS in a pedigree with a known hnRNPA1 variant was described to raise early ...
Xiaochen Han, Feixia Zhan, Yuxin Yao, Li Cao, Jianguo Liu, Sheng Yao   +5 more
wiley   +1 more source

The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1941-1952, December 2022., 2022
Abstract Objective The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA‐PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme replacement.
Michelle M. Lee, Graeme S. V. McDowell, Darryl C. De Vivo, Daniel Friedman, Samuel F. Berkovic, Maria Spanou, Argirios Dinopoulos, Katheryn Grand, Pedro A. Sanchez‐Lara, Michelle Allen‐Sharpley, Jodi Warman‐Chardon, Alexander Solyom, Thierry Levade, Edward H. Schuchman, Steffany A. L. Bennett, David A. Dyment, Toni S. Pearson   +16 more
wiley   +1 more source

Fatty acid metabolism by the osteoblast [PDF]

Bone, 2018
The emergence of bone as an endocrine organ able to influence whole body metabolism, together with comorbid epidemics of obesity, diabetes, and osteoporosis, have prompted a renewed interest in the intermediary metabolism of the osteoblast. To date, most studies have focused on the utilization of glucose by this specialized cell, but the oxidation of ...
Ryan C. Riddle, Ryan C. Riddle, Priyanka Kushwaha, Michael J. Wolfgang   +3 more
openaire   +3 more sources

Fatty Acid Metabolism in Endothelial Cell

Genes, 2022
The endothelium is a monolayer of cells lining the inner of blood and lymphatic vessels. Endothelial cells (ECs) release subtracts that prevent platelet and leukocyte adhesion and aggregation and modulate blood flow, which is essential for the normal function of the vascular system. ECs play indispensable roles in angiogenesis, homeostasis, stimulus or
Bin Liu, Zhiyu Dai
openaire   +2 more sources

Quantitative constraint-based computational model of tumor-to-stroma coupling via lactate shuttle [PDF]

Scientific Reports 5, 11880 (2015), 2015
Cancer cells utilize large amounts of ATP to sustain growth, relying primarily on non-oxidative, fermentative pathways for its production. In many types of cancers this leads, even in the presence of oxygen, to the secretion of carbon equivalents (usually in the form of lactate) in the cell's surroundings, a feature known as the Warburg effect.
arxiv   +1 more source

THBS1, a fatty acid-related metabolic gene, can promote the development of laryngeal cancer

Scientific Reports, 2022
Laryngeal cancer is the second most prevalent head and neck tumor and it is one of the most common malignancies of the upper respiratory tract. Fatty acid metabolism affects cancer cell biology in several ways, and alterations in fatty acid metabolism ...
Fei-Hong Ji, Xin-Guang Qiu
doaj   +1 more source

Metabolism of fatty acids by bovine spermatozoa [PDF]

Biochemical Journal, 1972
The incorporation of 14C-labelled myristic, palmitic, stearic, oleic and linoleic acids in vitro into the lipids of bovine spermatozoa was measured at intervals from 2min to 2h. All acids were rapidly incorporated into diglycerides, myristic acid being metabolized to the greatest extent.
A. R. Neill, C. J. Masters
openaire   +6 more sources

Weighted gene co-expression network analysis identified hub genes critical to fatty acid composition in Gushi chicken breast muscle

BMC Genomics, 2023
Background The composition and content of fatty acids in the breast muscle are important factors influencing meat quality. In this study, we investigated the fatty acid composition and content in the breast muscle of Gushi chickens at different ...
Bin Zhai, Yinli Zhao, Hongtai Li, Shuaihao Li, Jinxing Gu, Hongyuan Zhang, Yanhua Zhang, Hong Li, Yadong Tian, Guoxi Li, Yongcai Wang   +10 more
doaj   +1 more source

EPHX2 Inhibits Colon Cancer Progression by Promoting Fatty Acid Degradation

Frontiers in Oncology, 2022
Tumor cells use metabolic reprogramming to keep up with the need for bioenergy, biosynthesis, and oxidation balance needed for rapid tumor division. This phenomenon is considered a marker of tumors, including colon cancer (CRC).
Yiran Zhou, Yiran Zhou, Xiao Li, Xiao Li, Aoran Guan, Aoran Guan, Haodong Zhou, Haodong Zhou, Yankun Zhu, Yankun Zhu, Ruotian Wang, Ruotian Wang, Ruhong Li, Ruhong Li   +13 more
doaj   +1 more source

Radical-free hyperpolarized MRI using endogenously-occurring pyruvate analogues and UV-induced nonpersistent radicals [PDF]

, 2020
It was demonstrated that nonpersistent radicals can be generated in frozen solutions of metabolites such as pyruvate by irradiation with ultraviolet (UV) light, enabling radical-free dissolution DNP. Although pyruvate is endogenous, an excess of additional pyruvate may perturb metabolic processes, making it potentially unsuitable as a polarizing agent ...
arxiv   +1 more source