Results 71 to 80 of about 3,900,867 (308)

Advances in fatty acid metabolism in the tumor microenvironment of colorectal cancer

肿瘤影像学, 2022
 In recent years, the incidence of colorectal cancer in China has been increasing year on year, with the incidence of the disease tending to be younger and colorectal cancer is considered to be an obesity-related cancer.
ZHANG Xiao, YUAN Zheng, LIN Guangwu
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

THBS1, a fatty acid-related metabolic gene, can promote the development of laryngeal cancer

Scientific Reports, 2022
Laryngeal cancer is the second most prevalent head and neck tumor and it is one of the most common malignancies of the upper respiratory tract. Fatty acid metabolism affects cancer cell biology in several ways, and alterations in fatty acid metabolism ...
Fei-Hong Ji, Xin-Guang Qiu
doaj   +1 more source

Fatty acid composition of plasma lipids in healthy Portuguese children: Is the Mediterranean diet disappearing? [PDF]

, 2001
Background: Adults and children in Mediterranean countries are believed to consume a Mediterranean-type diet wh ich is h ig her in monounsaturated a nd n-3 polyunsaturated fatty acids than compared to central and northern parts of Europe and has ...
Feldl, Franziska, Guerra, Antonio, Koletzko, Berthold   +2 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress [PDF]

, 2010
Although dietary fatty acids are a major fuel for the heart, little is known about the direct effects of dietary fatty acids on gene regulation in the intact ...
Degenhardt, Tatjana, Boekschoten, M.V., Kersten, A.H., Boekschoten, Mark V., Georgiadi, Anastasia, Lichtenstein, Laeticia, Müller, Michael, Georgiadi, A., Bilsen, M., van, van Bilsen, Marc, Müller, M.R., Lichtenstein, L.L., Desvergne, Beatrice, Degenhardt, T., Desvergne, B., Boekschoten, Mark V, van Bilsen, M., Kersten, Sander, Kersten, S., Müller, M., Lichtenstein, L.   +20 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Ruminal microbiome–host metabolome crosstalk in the synthesis of unsaturated fatty acids in buffalo milk

Journal of Dairy Science
: Interactions between rumen microorganisms and their metabolites contribute to milk yield and milk fat content in dairy cows. However, whether rumen microbes and host metabolism affect fatty acid synthesis in milk is unknown.
Ye Yu, Runqi Fu, Chunjia Jin, Huan Gao, Lin Han, Min Qi, Binlong Fu, Qian Li, Yuyan Wang, Yanfen Cheng, Jing Leng   +10 more
doaj   +1 more source