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Mitochondrial fatty acid oxidation drives senescence. [PDF]
Sci AdvCellular senescence is a stress-induced irreversible cell cycle arrest involved in tumor suppression and aging. Many stresses, such as telomere shortening and oncogene activation, induce senescence by damaging nuclear DNA. However, the mechanisms linking DNA damage to senescence remain unclear.
Yamauchi S +11 more
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Foods, 2023 Numerous investigations have shown that insoluble dietary fiber (IDF) has a potentially positive effect on obesity due to a high-fat diet (HFD). Our previous findings based on proteomic data revealed that high-purity IDF from soybean residue (okara ...
Jiarui Zhang +7 more
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Integrated Control of Fatty Acid Metabolism in Heart Failure
Metabolites, 2023 Disrupted fatty acid metabolism is one of the most important metabolic features in heart failure. The heart obtains energy from fatty acids via oxidation. However, heart failure results in markedly decreased fatty acid oxidation and is accompanied by the
Xiaoting Li, Xukun Bi
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Frontiers in Pharmacology, 2022 The kidney is a highly metabolic organ and requires a large amount of ATP to maintain its filtration-reabsorption function, and mitochondrial fatty acid β-oxidation serves as the main source of energy to meet its functional needs. Reduced and inefficient
Zhumei Gao, Xiangmei Chen, Xiangmei Chen
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Fatty acid oxidation disorders [PDF]
Annals of Translational Medicine, 2018 Fatty acid oxidation disorders (FAODs) are inborn errors of metabolism due to disruption of either mitochondrial β-oxidation or the fatty acid transport using the carnitine transport pathway. The presentation of a FAOD will depend upon the specific disorder, but common elements may be seen, and ultimately require a similar treatment.
J Lawrence, Merritt +2 more
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Frontiers in Bioscience-Landmark, 2022 Fatty acid metabolism has attracted extensive attention for its key role in the occurrence and development of tumors. Fatty acids not only participate in the biosynthesis of phospholipids in the membrane to overcome the demand for rapidly proliferating ...
Hongdan Chen +5 more
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l‐Carnitine therapy improves right heart dysfunction through Cpt1‐dependent fatty acid oxidation
Pulmonary Circulation, 2022 Pulmonary arterial hypertension (PAH) is a fatal vasculopathy that ultimately leads to elevated pulmonary pressure and death by right ventricular (RV) failure, which occurs in part due to decreased fatty acid oxidation and cytotoxic lipid accumulation ...
Vineet Agrawal +10 more
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Energy metabolism in skeletal muscle cells from donors with different body mass index
Frontiers in Physiology, 2022 Obesity and physical inactivity have a profound impact on skeletal muscle metabolism. In the present work, we have investigated differences in protein expression and energy metabolism in primary human skeletal muscle cells established from lean donors ...
Parmeshwar B. Katare +9 more
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Fatty acid oxidation assay [PDF]
Protocol Exchange, 2006 Lily Dong, Feng Liu
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Myoglobin regulates fatty acid trafficking and lipid metabolism in mammary epithelial cells
PLoS ONE, 2022 Myoglobin (MB) is known to bind and deliver oxygen in striated muscles at high expression levels. MB is also expressed at much reduced levels in mammary epithelial cells, where the protein´s function is unclear. In this study, we aim to determine whether
Julia Armbruster +12 more
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