Results 221 to 230 of about 496,965 (359)

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, EarlyView.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

Myopathic Symptoms and Exercise Tolerance in Adolescent Patients With Long-Chain Fatty Acid Oxidation Disorders. [PDF]

J Inherit Metab Dis
Schwantje M, van Brussel M, Takken T, de Sain-van der Velden MGM, Langeveld M, Visser G, Fuchs SA.   +6 more
europepmc   +1 more source

Data from C/EBPa confers dependence to fatty acid anabolic pathways and vulnerability to lipid oxidative stress-induced ferroptosis in FLT3-mutant leukemia

Marie Sabatier, Rudy Birsen, Laura Lauture, Sarah Mouche, Paolo Angelino, Jonas Dehairs, Léa Goupille, Ismael Boussaïd, Maël Heiblig, Emeline Boët, Ambrine Sahal, Estelle Saland, Juliana C. Santos, Marc Armengol, Miranda Fernández-Serrano, Thomas Farge, Guillaume Cognet, Federico Simonetta, Corentin Pignon, Antoine Graffeuil, Céline Mazzotti, Hervé Avet‐Loiseau, Océane Delos, Justine Bertrand‐Michel, Amélie Chedru, Vilma Dembitz, Paolo Gallipoli, Natasha S. Anstee, Sun Loo, Andrew H. Wei, Martin Carroll, Armelle Goubard, Rémy Castellano, Yves Collette, François Vergez, Véronique Mansat‐De Mas, Sarah Bertoli, Suzanne Tavitian, Muriel Picard, Christian Récher, Nathalie Bourgès‐Abella, Fanny Granat, Olivier Kosmider, Pierre Sujobert, Benoît Colsch, Carine Joffre, Lucille Stuani, Johannes V. Swinnen, Hervé Guillou, Gaël Roué, Nawad Hakim, Anne S. Dejean, Petros Tsantoulis, Clément Larrue, Didier Bouscary, Jérôme Tamburini, Jean‐Emmanuel Sarry   +56 more
openalex   +1 more source

Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma, Zhenbo Han, Jooman Park, Gege Yan, Sen Zhang, Youjeong Kwon, Sarath Babu Nukala, Jindpreet Kandola, Sandra Pinho, Chong Wee Liew, Yuwei Jiang, Sang‐Ging Ong   +11 more
wiley   +1 more source

The role and mechanism of fatty acid oxidation in cancer drug resistance. [PDF]

Cell Death Discov
Lei Y, Cai S, Zhang JK, Ding SQ, Zhang ZH, Zhang CD, Dai DQ, Li YS.   +7 more
europepmc   +1 more source

Deciphering theBiological Decarboxylation Mechanismof Fatty Acids in Diiron Oxidative Decarboxylase UndA: Key Role ofthe Adaptive First Coordination Sphere

Ya-Ru Sheng (20296546), Chao Wang (146527), Hui Chen (28597)   +2 more
openalex   +1 more source

2‐line Ferrihydrite Enhance Microbial Synthesis of Plant Biostimulants in Composted Biosolid by Regulating Phyla Pseudomonadota and Actinomycetota

Advanced Science, EarlyView.
This study explores how iron and manganese oxides transform sewage sludge into plant biostimulants during composting. Non‐targeted identification reveals the main species of plant biostimulants. Metagenomic analysis reveals that 2‐line ferrihydrite specifically enriches microbial genes for biosynthesis, boosting plant‐growth promoters.
Yu Zhang, Ziwei Zhang, Zexu Chen, Boyuan Yang, Siying Cai, Jun Chen, Jianhua Guo, Weijun Zhang   +7 more
wiley   +1 more source

Oral octanoylcarnitine alleviates exercise intolerance in mouse models of long-chain fatty acid oxidation disorders. [PDF]

JCI Insight
Solo KJ, Zhang Y, Bharathi SS, Zhang BB, Richert AC, Schmidt AV, Van't Land C, D'Annibale O, Wood TC, Goetzman ES.   +9 more
europepmc   +1 more source

Tumor‐Derived CDC37 Inhibits Antigen Cross‐Presentation in Dendritic Cells and Impairs Anti‐Tumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Extracellular vesicle (EV)‐packaged CDC37 are released from TMBhiCTLlo breast cancer cells with high CDC37 expression, and internalized into endo/phagosomes of dendritic cells (DCs). Within these compartments, CDC37 locked HSP90–antigen complex, preventing antigen release into the cytosol.
Ruxin Wang, Yunyi Zhang, Xiangyu Meng, Jianli Zhao, Yue Xing, Qian Ouyang, Ning Zhang, Huiping Chen, Nanyan Miao, Erwei Song, Di Huang   +10 more
wiley   +1 more source

Fenofibrate alleviates sepsis-associated acute kidney injury by enhancing renal fatty acid oxidation. [PDF]

BMC Pharmacol Toxicol
Zeng S, Wang J, Guan C, Yao Z, Zhang Y, Li Y, Zheng J, Wang H.   +7 more
europepmc   +1 more source