Results 191 to 200 of about 349,684 (263)

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

<i>Humulus lupulus</i> L. in Animal Nutrition: Phytochemical Profile, Bioactive Properties, and Applications as a Functional Feed Additive-A Comprehensive Review. [PDF]

Plants (Basel)
Zepeda C, López J, Figueroa C, Low C, Olivares-Cantillano G.   +4 more
europepmc   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Safflower (<i>Carthamus tinctorius</i> L.) Seed Oils: Effect of Extraction Process and Cultivars on Chemical Composition, Physicochemical Parameters and Nutritional Quality Index. [PDF]

Food Sci Nutr
El Kourchi C, Belhoussaine O, Ali RM, Amakhmakh M, Sumaily KM, Santanatoglia A, Maggi F, Caprioli G, Bouyahya A, Tabyaouı M, Harhar H.   +10 more
europepmc   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Coriander leaf essential oil as an immunomodulator: Enhancing NF-κB-driven RAW246.7 murine macrophages response to Candida albicans. [PDF]

PLoS One
Hiengrach P, Sangsiwarit P, Kuwatjanakul W, Samerpitak K, Luksanawilas P.   +4 more
europepmc   +1 more source

Unveiling Lactylation: A Novel Frontier in Cancer Stemness and Therapy

Advanced Science, EarlyView.
Tumor metabolism and epigenetic regulation are intrinsically linked. This review highlights lactylation as a pivotal bridge connecting these processes, acting as an active epigenetic effector in cancer stemness. We delineate how lactylation orchestrates the cancer stem cell landscape and evaluate its regulatory networks.
Ting Li, Hongyu Gu, Chang Liu, Yuesheng Lv, Feifei Li, Liang Liang, Jia Yi, Xuanyi Wang, Yi Zhun Zhu, Chuan Xu   +9 more
wiley   +1 more source

Variations in Plankton Community Structure Between Freshwater and Saline-Alkaline Waters and Their Correlation with Nutrient Composition in <i>Macrobrachium nipponense</i>. [PDF]

Animals (Basel)
Jin S, Ye Z, Fu H, Xiong Y, Qiao H, Zhang W, Jiang S.   +6 more
europepmc   +1 more source

Iron‐Mediated Release of Aged Dissolved Organic Carbon From Waterlogged Peatland Under Warming

Advanced Science, EarlyView.
This study conducts a five‐year in situ warming experiment in high‐altitude peatlands to examine dissolved organic carbon (DOC) release. The study shows that warming promotes the release of plant‐derived modern DOC in drained peatlands, but amplifies aquatic export of century‐old DOC from waterlogged peatlands via Fe‐mediated DOC mobilization—a ...
Guohua Dai, Zhiying Yang, Zongguang Liu, Wanjia Hu, Lixiao Ma, Enze Kang, Wanqing Luo, Yunpeng Zhao, Chengzhu Liu, Juan Jia, Ting Liu, Chen He, Quan Shi, Jianliang Liu, Yongheng Gao, Huai Chen, Hailong Zhang, Meixun Zhao, Xiaojuan Feng   +18 more
wiley   +1 more source

Evaluating the beneficial role of bio-inoculants (Bradyrhizobium and arbuscular mycorrhizal fungi) in improving the nutritional value and metabolic profile of soybean seeds. [PDF]

Sci Rep
Sheteiwy MS, El-Sawah AM, Ali B, Dawood MFA, Jośko I, Feculak M, El-Keblawy A, Ulhassan Z, Wang W, Okla MK, Alaraidh IA, Abdel-Fattah GG.   +11 more
europepmc   +1 more source