Results 71 to 80 of about 349,684 (263)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Candidate genes associated with fatty acid compositions in north American Atlantic salmon (Salmo salar)

BMC Genomics
Fatty acids are a requirement for normal development, however, since humans are unable to de novo produce essential fatty acids, they must be obtained from diet. Atlantic salmon is a major dietary source of nutritious and digestible fatty acids. Here, we
Barbara L. Langille, Manuel Juárez, Nuria Prieto, Solomon Boison, Panya Sae Lim, Bruce D. Swift, Amber F. Garber   +6 more
doaj   +1 more source

The influence of exogenous cholesterol on hepatic lipid composition of the rat*

Journal of Lipid Research, 1962
Rats were fed diets containing cottonseed oil and/or cholesterol, cholic acid, methyl esters of long-chain fatty acids, and tocopherol. Livers, hearts, and aortas were examined histologically; liver lipids were fractionated by silicic acid chromatography;
Robert J. Morin, Sol Bernick, James F. Mead, Roslyn B. Alfin-Slater   +3 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Fetal alcohol syndrome and essential fatty acids. [PDF]

PLoS Medicine, 2006
Undurti N Das
doaj   +1 more source

CHANGES IN PLASMA LIPID COMPOSITION IN PATIENTS WITH ESSENTIAL HYPERTENSION

Российский кардиологический журнал, 2003
To examine the relation between serum fatty acids, blood pressure and heart failure in hypertensive patients we conducted a study of 58 patients with essential hypertension (mean age 45,1 ± 9,4 years) and 22 healthy subjects.
A. V. Govorin, N. V. Lareva, B. S. Hyshiktuyev, A. P. Filev   +3 more
doaj  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Deposition of Dietary Bioactive Fatty Acids in Tissues of Broiler Chickens

The Journal of Poultry Science, 2017
This study examined the deposition of dietary bioactive fatty acids (FAs), including medium-chain and essential FAs, in tissues of broiler chickens. Six hundred newly hatched chicks were allotted to 4 treatments, 6 replicates of 25 chicks per treatment.
Huan-Chin Chu, Shu-Hsing Chiang
doaj   +1 more source