Results 181 to 190 of about 13,450 (208)

Nonesterified fatty acids, cognitive decline, and dementia

Current Opinion in Lipidology, 2020
Purpose of review Dementia is rapidly growing as sources of morbidity and mortality as the US population ages, but its pathophysiology remains poorly understood. As a result, no disease-modifying treatments currently exist. We review the evidence that nonesterified fatty acids may play a key role in this condition.
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The Significance of Nonesterified Fatty Acids in Plasma

Archives of Internal Medicine, 1958
Recent studies have clarified some aspects of fatty acid transport. The results promise to be of clinical importance, since fat, as a major energy source and as a component of body structure, plays a central role in chronic diseases of metabolism. For example, obesity can be conceived as an abnormal balance between the total amount of fatty acid stored
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Cellular Transport of Nonesterified Fatty Acids

Journal of Molecular Neuroscience, 2001
Transport of nonesterified fatty acids (NEFA) is an important component of whole-body energy metabolism, and derangements in NEFA transport have been linked to several diseases. NEFA are transferred from their sites of production to cells in hepatic and peripheral tissues by mechanisms that are regulated in part by cell status and as determined by the ...
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Sensitive micro determination of nonesterified fatty acids

Microchemical Journal, 1972
Abstract A procedure is described in which an extremely sensitive copper ligand, TETD, is used as a substitute for DDC in the indirect determination of NEFA. The latter was isolated by extraction into chloroform as a copper soap followed by reaction between TETD and the copper in acid solution.
Adam Manasterski, R. Watkins, Bennie Zak
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Effect of nonesterified fatty acids on the stability of prostacyclin activity

Metabolism, 1983
The half-life of the platelet antiaggregatory activity of prostacyclin (PGI2) is prolonged when PGI2 is incubated in human plasma or in fatty-acid-free human albumin solutions. This "PGI2-protective" effect is diminished when fatty acids are added to the incubate, and the diminution is proportional to the concentration of the nonesterified fatty acids ...
Alice M. Mikhailidis, Dimitri P. Mikhailidis, M.A. Barradas, Paresh Dandona   +3 more
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Nonesterified fatty acids in the pathogenesis of hypertension: theory and evidence

Prostaglandins, Leukotrienes and Essential Fatty Acids, 1997
This paper approaches the hypothesis that fatty acids contribute to hypertension by examining possible interactions of nonesterified fatty acids with renal pressure-natriuresis, peripheral vascular resistance, and the central nervous barostat, three loci where long-term regulation of blood pressure is probably controlled.
Theodore L. Goodfriend, Theodore L. Goodfriend, B.M. Egan, B.M. Egan   +3 more
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Accumulation of nonesterified fatty acids in ischemic canine myocardium

American Journal of Physiology-Heart and Circulatory Physiology, 1984
In ischemic myocardium the time course of nonesterified fatty acid (NEFA) accumulation was studied in relation to changes in regional metabolism and mechanics. In open-chest dogs a coronary artery was partially occluded for 120 min. In the ischemic myocardium no increase was observed in NEFA content within 10 min, whereas changes were found in ...
Will A. Coumans, Robert S. Reneman, Frits W. Prinzen, Theo Arts, G. J. Van Der Vusse, Theo H.M. Roemen   +5 more
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Mechanisms of interference of nonesterified fatty acids in radioimmunoassays of steroids

Clinica Chimica Acta, 1979
Addition of nonesterified fatty acids caused an apparent increase in unbound steroid present in supernatants in radioimmunoassays for steroids utilizing dextran-coated charcoal. Nonesterified fatty acid interference occurred at the initial binding interaction between steroid and its antiserum, and also at the step separating bound from unbound steroid.
Judith M. Rash, Ivanka Jerkunica, Demetrios S. Sgoutas   +2 more
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Nonesterified fatty acids and endothelial dysfunction

International Congress Series, 2003
Nonesterified fatty acids (NEFA) induce vascular effects, such as the inhibition of insulin-induced nitric oxide (NO) production. In small arteries, relaxation is largely NO-independent. We aimed to assess the effect of elevated NEFA on NO-independent vasodilation. Protocols were performed before and after 120 min of a lipid emulsion infusion.
AVOGARO, ANGELO, DE KREUTZENBERG S, KIWANUKA E, TIENGO, ANTONIO   +3 more
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Mono‐ and polyenoic acid distribution in plasma nonesterified fatty acids in Kwashiorkor

Lipids, 1971
AbstractPlasma NEFA levels were determined in Kwashiorkor (17 cases) and normal infants (13 cases) by Dole's method. The distribution of mono‐ and polyenoic acids was investigated by Abdel‐Wahab's method. Plasma NEFA levels were found to be significantly lower in Kwashiorkor infants (445 μEq/L±32) than in normals (591 μEq/L±66).
F. Abdel-Wahab, K. Fayek, I. Fayad, A. A. Hafiez, K. Khalifa, L. Soliman   +5 more
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