The effect of nonesterified fatty acids and progesterone on bupivacaine protein binding
Clinical Pharmacology and Therapeutics, 1986We examined the influence of elevations in levels of nonesterified fatty acids (NEFAs) and progesterone concentrations on bupivacaine protein binding. The addition of NEFAs to isolated binding proteins of bupivacaine (alpha 1-acid glycoprotein and serum albumin) resulted in an increased binding to alpha 1-acid glycoprotein and an inconsistent decrease ...
Dennis E. Coyle +3 more
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Nonesterified fatty acids in blood pressure control and cardiovascular complications
Current Hypertension Reports, 2001The fact that cardiovascular risk factors cluster among individuals with the insulin resistance syndrome strongly suggests a common pathogenetic denominator. For many years, abnormalities of nonesterified fatty acid metabolism have been implicated in the disturbances of carbohydrate and lipid metabolism that characterize the cluster.
Theodore L. Goodfriend +2 more
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Nonesterified fatty acids modulate steroidogenesis in mouse Leydig cells
American Journal of Physiology-Endocrinology and Metabolism, 1989The effects of nonesterified fatty acids (NEFA) in modulating testosterone synthesis stimulated by luteinizing hormone (LH, 10 ng/sample) were investigated in isolated adult mouse Leydig cells. LH-stimulated testosterone production was inhibited by triglycerides (0-500 mg/dl, 50 mg/dl, 94% of the control and 500 mg/dl, 40%) and by a mixture of NEFA ...
W. D. Boam +4 more
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Nonesterified Fatty Acids and Development of Graft Failure in Renal Transplant Recipients
Transplantation, 2013Chronic transplant dysfunction is the most common cause of graft failure on the long term. Proteinuria is one of the cardinal clinical signs of chronic transplant dysfunction. Albumin-bound fatty acids (FA) have been hypothesized to be instrumental in the etiology of renal damage induced by proteinuria.
Henri G. D. Leuvenink +7 more
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Assay of Serum Nonesterified Fatty Acids by Atomic Absorption Spectrophotometry
American Journal of Clinical Pathology, 1973Assay of nonesterified fatty acids in 100 μ l. of serum is described. The fatty acids are extracted with chloroform-heptane-methanol solvent, and their copper complexes are determined by atomic absorption spectrophotometry. This technic possesses the sensitivity (20 μ moles per 1.) and reliability (4.2% coefficient of variation) required for clinical ...
Derek P. Lehane, Mario Werner
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Effects of Nonesterified Fatty Acids on Glucose Metabolism After Glucose Ingestion
Diabetes, 1997Impaired suppression of plasma nonesterified fatty acids (NEFAs) after glucose ingestion may contribute to glucose intolerance, but the mechanisms are unclear. Evidence that insulin inhibits hepatic glucose output (HGO), in part by suppressing plasma NEFA levels, suggests that impaired suppression of plasma NEFA after glucose ingestion would impair HGO
Joseph G. Yu +4 more
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THE EFFECT OF SALICYLATE ON PLASMA NONESTERIFIED FATTY ACIDS
The American Journal of the Medical Sciences, 1963Rupp Jj, Gilgore Sg, Drew Wl
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Observations on the Peripheral Metabolism of Nonesterified Fatty Acids
Diabetes, 1959Guy Schless, W. J. H. Butterfield
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Serum Triglycerides and Nonesterified Fatty Acids in Kwashiorkor
The American Journal of Clinical Nutrition, 1966P. S. K. Prasad, K. S. J. Rao
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An Abnormality of Nonesterified Fatty Acid Metabolism in Diabetes Mellitus
Diabetes, 1957Thomas N Roberts +2 more
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