Results 91 to 100 of about 1,436,231 (357)

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Seasonal changes of fatty acids in Nerita textiles on intertidal area of Chabahar Bay (Oman Sea)

‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2012
The aim of this research was to identify and isolate the fatty acids composition of Nerita textiles in intertidal area of Chabahar Bay, and also to explore the seasonal changes of fatty acid content in Nerita textiles.
N. Sajjadi email ; P. Eghtesadi; K. Darvish Bastami
doaj  

Metabolomics of dietary fatty acid restriction in patients with phenylketonuria [PDF]

, 2012
Patients with phenylketonuria (PKU) have to follow a lifelong phenylalanine restricted diet. This type of diet markedly reduces the intake of saturated and unsaturated fatty acids especially long chain polyunsaturated fatty acids (LC-PUFA).
Berthold Koletzko, Carmen Rohde, Claudia Matthies, Joachim Thiery, Linda Kortz, Mathias Bruegel, Michael Müller, Skadi Beblo, Ulrike Mütze, Uta Ceglarek, Wieland Kiess   +10 more
core   +3 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Evaluation of Types and Amounts of Fatty Acid Content in some most Consumed Iranian Fast Foods

مجله دانشکده پزشکی اصفهان, 2009
Background:There is an important concern about the intake of foods which contains trans fatty acids due to their harmful effects on human health. Although adverse affects of trans fatty acids on the cardiovascular system were established, but a few data ...
Bahar Nazari, Seddigeh Asgary, Nizal Sarrafzadegan, Salbali Saberi, Leila Azadbakht, Ahmad Esmaillzadeh   +5 more
doaj  

Content of fatty acids, vitamin E and carotenoids in milk and herbage as affected by sward composition and period of grazing [PDF]

, 2011
The quality of organic milk is affected by feed composition, and especially the high use of legumes has been identified as the reason for high levels of polyunsaturated fatty acids, carotenoids and tocopherols in organic milk. Four different pastures
Eriksen, J., Fretté, Xavier C., Kristensen, Troels, Larsen, Mette Krogh, Nielsen, J.H., Søegaard, Karen   +5 more
core  

Generation of cloned transgenic pigs rich in omega-3 fatty acids [PDF]

, 2006
Meat products are generally low in omega-3 (n-3) fatty acids, which are beneficial to human health. We describe the generation of cloned pigs that express a humanized Caenorhabditis elegans gene, fat-1, encoding an n-3 fatty acid desaturase.
August Rieke, Clifton N Murphy, David M Wax, Hwan Yul Yong, Jing X Kang, Jingdong Wang, JP Spychalla, JX Kang, L Lai, Liangxue Lai, Melissa Samuel, Michael L Linville, PRC Howe, Randall S Prather, Rhobert W Evans, Rongfeng Li, Scott W Korte, Thomas E Starzl, William T Witt, Y Dai, Yanhong Hao, Yifan Dai   +21 more
core   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Tannin, protein contents and fatty acid compositions of the seeds of several Vicia L. species from Turkey

Grasas y Aceites, 2010
The seedoils of six Vicia species (Leguminosae) were investigated for their protein, tannin contents and fatty acid compositions. The protein contents of the seeds were found to be between 21.87%-31.33%.
Kağan Kökten, Alpaslan Koçak, Eyüp Bağci, Mevlüt Akçura, Sait Çelik   +4 more
doaj   +1 more source