Results 101 to 110 of about 2,963,117 (406)

Combined evaluation of Fibrosis‐4 index and fatty liver for stratifying the risk for diabetes mellitus

Journal of Diabetes Investigation, 2022
Aims/Introduction To investigate whether the Fibrosis‐4 index can help stratify the risk of diabetes mellitus in patients with fatty liver disease.
Yasuhiko Todo, Teruki Miyake, Shinya Furukawa, Bunzo Matsuura, Toru Ishihara, Masumi Miyazaki, Akihito Shiomi, Hironobu Nakaguchi, Sayaka Kanzaki, Yasunori Yamamoto, Yohei Koizumi, Osamu Yoshida, Yoshio Tokumoto, Masashi Hirooka, Eiji Takeshita, Teru Kumagi, Yoshio Ikeda, Masanori Abe, Takeru Iwata, Yoichi Hiasa   +19 more
doaj   +1 more source

Dietary chia seed (Salvia hispanica L.) rich in a-linolenic acid improves adiposity and normalises hypertriacylglycerolaemia and insulin resistance in dyslipaemic rats [PDF]

, 2009
The present study investigates the benefits of the dietary intake of chia seed (Salvia hispanica L.) rich in α-linolenic acid and fibre upon dyslipidaemia and insulin resistance (IR), induced by intake of a sucrose-rich (62.5 %) diet (SRD).
Chicco, Adriana Graciela, D'alessandro, Maria Eugenia Guadalupe, Hein, Gustavo Juan, Lombardo, Yolanda B., Oliva, Maria Eugenia   +4 more
core   +1 more source

Nonalcoholic fatty liver disease [PDF]

Nature Reviews Disease Primers, 2015
Nonalcoholic fatty liver disease (NAFLD) is a disorder characterized by excess accumulation of fat in hepatocytes (nonalcoholic fatty liver (NAFL)); in up to 40% of individuals, there are additional findings of portal and lobular inflammation and hepatocyte injury (which characterize nonalcoholic steatohepatitis (NASH)).
Brunt, Elizabeth M, Wong, Vincent W. S., Nobili, Valerio, Day, Christopher P., Sookoian, Silvia, Maher, Jacquelyn J., BUGIANESI, Elisabetta, Sirlin, Claude B., Neuschwander Tetri, Brent A., Rinella, Mary E.   +9 more
openaire   +6 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Navigating hepatotoxicity of antibody-drug conjugates: from mechanistic insights to clinical and postmarketing evidence

Frontiers in Pharmacology
Antibody-drug conjugates (ADCs) are rapidly developing targeted cancer therapeutic agents that combine specific monoclonal antibodies with cytotoxic agents. Currently, 17 ADCs are approved for the global market for treating hematological and solid tumors
Yinuo Dong, Yang Zhi, Xiaoyun Li, Xiaoyun Li, Mingyang Ma, Minyan Ye, Sha Huang, Jieting Tang, Wei Zhong, Xiaohong Lei, Yimin Mao   +10 more
doaj   +1 more source

Correlation of Ultrasound Acoustic Radiation Force Impulse Elastography with Sonographic Severity Grading of Fatty Liver Disease [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: Fatty liver is one of the commonly encountered incidental finding in routine ultrasonography practice. The fatty liver has been divided into three grades according to severity based on the degree of increased liver echotexture on ...
Varsha P Rangankar, Priya R Bhole, Sarang S Gosavi, Sarang R Rathod   +3 more
doaj   +1 more source

Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood. [PDF]

, 2016
Excess collagen synthesis (fibrogenesis) in the liver plays a causal role in the progression of nonalcoholic fatty liver disease (NAFLD). Methods are needed to identify patients with more rapidly progressing disease and to demonstrate early response to ...
Angel, Thomas E, Beysen, Carine, Brenner, David A, Colangelo, Marc, Cui, Jeffrey, Decaris, Martin L, Emson, Claire L, Gatmaitan, Michelle, Hellerstein, Marc K, Hernandez, Carolyn, Lazaro, Len, Li, Kelvin W, Liu, Shanshan, Loomba, Rohit, Nyangau, Edna, Turner, Scott M, Wang, Yenny   +16 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Non-invasive tests for MetALD and alcohol-related liver diseaseKeypoints

JHEP Reports
Summary: Metabolic- and alcohol-related liver disease (MetALD) and alcohol-related liver disease (ALD) are major drivers of the global burden of cirrhosis. While metabolic dysfunction-associated steatotic liver disease (MASLD) affects nearly one-third of
Stine Johansen, Maja Thiele, Aleksander Krag   +2 more
doaj   +1 more source

A multistakeholder approach to innovations in NAFLD care

Communications Medicine, 2023
Schattenberg et al. outline discussions from a recent workshop on NAFLD care and advocate for a multidisciplinary approach to managing this complex and multifactorial disease.
Jörn M. Schattenberg, Alina M. Allen, Helen Jarvis, Shira Zelber-Sagi, Ken Cusi, John F. Dillon, Cyrielle Caussy, Sven M. Francque, Zobair Younossi, Naim Alkhouri, Jeffrey V. Lazarus   +10 more
doaj   +1 more source