Results 51 to 60 of about 395,992 (296)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Protection technology of coal mine power based on GOOSE network with information sharing

open access: yesGong-kuang zidonghua, 2015
For problems of override trip in short-circuit fault and fault line selection in single-phase earth fault of coal mine power system, a protection technology of coal mine power based on GOOSE network with information sharing was proposed.
YAO Fuqiang, BAI Meng, ZOU Wenbing
doaj   +1 more source

AI and OR in management of operations: history and trends [PDF]

open access: yes, 2007
The last decade has seen a considerable growth in the use of Artificial Intelligence (AI) for operations management with the aim of finding solutions to problems that are increasing in complexity and scale.
Kobbacy, KAH, Rasmy, MH, Vadera, S
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Research of fault line selection method for small current grounding system based on multi-source information fusio

open access: yesGong-kuang zidonghua, 2013
In view of problem of difficult fault line selection for small current grounding system, the paper proposed a fault line selection method for small current grounding system based on multi-source information fusion.
HE Jin-peng, TIAN Shu, YANG Xin-ping
doaj  

Intelligent Fault Analysis in Electrical Power Grids

open access: yes, 2017
Power grids are one of the most important components of infrastructure in today's world. Every nation is dependent on the security and stability of its own power grid to provide electricity to the households and industries.
Bhattacharya, Biswarup, Sinha, Abhishek
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Application of EOS-ELM with binary Jaya-based feature selection to real-time transient stability assessment using PMU data

open access: yes, 2017
Recent studies show that pattern-recognition-based transient stability assessment (PRTSA) is a promising approach for predicting the transient stability status of power systems.
Li, Yang, Yang, Zhen
core   +1 more source

Pitting damage levels estimation for planetary gear sets based on model simulation and grey relational analysis [PDF]

open access: yes, 2011
The planetary gearbox is a critical mechanism in helicopter transmission systems. Tooth failures in planetary gear sets will cause great risk to helicopter operations.
Cheng, Zhe   +3 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

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