Results 51 to 60 of about 6,409 (268)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Flatness-based fault tolerant control

Dyna, 2014
Este artículo presenta un método de control tolerante a fallas para sistemas no lineales planos. Las propiedades intrínsecas d e los sistemas planos generan redundancia analítica y permiten calcular todos los estados y las entradas de control del sistema.
César Martínez-Torres, Loïc Lavigne, Franck Cazaurang, Efraín Alcorta-García, David A. Díaz-Romero   +4 more
doaj  

Open-Switch Fault Diagnosis Algorithm and Tolerant Control Method of the Three-Phase Three-Level NPC Active Rectifier

Energies, 2019
This paper proposes a fault diagnosis and tolerant control methods for an open-switch fault caused in a three-phase three-level neutral-point-clamped (NPC) pulse-width modulation (PWM) active rectifier. The open-switch fault in the three-level NPC active
Jun-Hyung Jung, Hyun-Keun Ku, Yung-Deug Son, Jang-Mok Kim   +3 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Fault tolerant control in an unmanned bicycle robot via sliding mode theory

IET Cyber-systems and Robotics, 2022
In this work, a new active fault tolerant control (FTC) is developed for an unmanned bicycle robot based on an integration between a sliding mode control (SMC), fault detection (FD), and fault estimation (FE) via a residual signal.
Mousa Alizadeh, Amin Ramezani, Hadis Saadatinezhad   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Fault Diagnosis and Fault-Tolerant Control Scheme for Quadcopter UAVs with a Total Loss of Actuator

Energies, 2019
Fault-tolerant control has drawn attention in recent years owning to its reliability and safe flight during missions. In this article, an active fault-tolerant control method is proposed to control a quadcopter in the presence of actuator faults and ...
Ngoc Phi Nguyen, Sung Kyung Hong
doaj   +1 more source

Reliability Modeling of Fault Tolerant Control Systems [PDF]

International Journal of Applied Mathematics and Computer Science, 2007
Reliability Modeling of Fault Tolerant Control SystemsThis paper proposes a novel approach to reliability evaluation for active Fault Tolerant Control Systems (FTCSs). By introducing a reliability index based on the control performance and hard deadline, a semi-Markov process model is proposed to describe system operation for reliability evaluation ...
Hongbin Li, Qing Zhao 0003, Zhenyu Yang 0001   +2 more
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Fault-Tolerant Model Predictive Control for Autonomous Underwater Vehicles Considering Unknown Disturbances

Journal of Marine Science and Engineering
This paper presents a fault-tolerant model predictive control approach for cross-rudder autonomous underwater vehicles to achieve heading control, considering rudder stuck faults and unknown disturbances.
Yimin Chen, Shaowen Hao, Jian Gao, Jiarun Wang, Le Li   +4 more
doaj   +1 more source