Results 91 to 100 of about 792,011 (298)
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Research of protection for AC transmission lines based on characteristic of grid-side inverter
The Journal of Engineering, 2019 With the advantage of saving resources and high utilisation, DC transmission becomes the vital part of the sustainable development. However, due to the control strategies of grid-side inverter, the fault characteristics of the grid will change ...
Ning Huang, Chunju Fan, Shan Jiang
doaj +1 more source
Superconducting Fault Current Limiter.
TEION KOGAKU (Journal of Cryogenics and Superconductivity Society of Japan), 1997 There is disclosed a current limiter having a plurality of current limiting units provided for electric paths constituting a plurality of phases, Each current limiting unit is constituted by a superconducting coil functioning as a first current limiting element formed in a non-inductive winding manner by connecting two superconducting coils in series ...
Takeshi OHKUMA, Yoshihiro IWATA
openaire +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Optimal power flow considering fault current level constraints and fault current limiters
International Journal of Electrical Power & Energy Systems, 2014 Abstract The aim of this paper is to present a novel method to dispatch the active generation power properly in the power system while incorporating fault current levels as constraints for the optimization problem. Due to the limited capacity of protective devices such as circuit breakers, allocating active power without considering fault current ...
Amirhossein Khazali, Mohsen Kalantar
openaire +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
A Hybrid DC Circuit Breaker with Fault-Current-Limiting Capability for VSC-HVDC Transmission System
Energies, 2019 The direct current circuit breakers are considered a promising option to protect the transmission line against commonly appearing line-to-ground fault.
Muhammad Ahmad, Zhixin Wang
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source