Results 91 to 100 of about 297,161 (352)

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Security and Privacy in Fog Computing: Challenges

IEEE Access, 2017
Fog computing paradigm extends the storage, networking, and computing facilities of the cloud computing toward the edge of the networks while offloading the cloud data centers and reducing service latency to the end users. However, the characteristics of
Mithun Mukherjee, Rakesh Matam, Lei Shu, Leandros Maglaras, Mohamed Amine Ferrag, Nikumani Choudhury, Vikas Kumar   +6 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Model-based sensor supervision inland navigation networks: Cuinchy-Fontinettes case study [PDF]

, 2014
In recent years, inland navigation networks benefit from the innovation of the instrumentation and SCADA systems. These data acquisition and control systems lead to the improvement of the manage- ment of these networks.
Blesa Izquierdo, Joaquim, Bolea Monte, Yolanda, Chuquet, Karine, Duviella, Eric, Horváth, Klaudia, Puig Cayuela, Vicenç, Rajaoarisoa, Lala H.   +6 more
core   +1 more source

Interturn Fault Diagnosis in Interior Permanent Magnet Synchronous Motors Using Negative-Sequence Impedance [PDF]

, 2017
Fault diagnosis is important due to the increasing demand of using interior permanent magnet synchronous machines (IPMSMs). In particular, an interturn fault is one of the most frequent electrical faults in IPMSMs.
김상우, 정혜윤
core   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Fault Diagnosis of Rotating Machinery Based on Wavelet Domain Denoising and Metric Distance

IEEE Access, 2019
In the monitoring process of petrochemical equipment rotating machinery, the collected large data easily lead to valuable data loss in the pre-processing process and affecting the accuracy of the fault diagnosis.
Naiquan Su, Xiao Li, Qianghua Zhang
doaj   +1 more source

Expert systems for real-time monitoring and fault diagnosis [PDF]

Methods for building real-time onboard expert systems were investigated, and the use of expert systems technology was demonstrated in improving the performance of current real-time onboard monitoring and fault diagnosis applications.
Caglayan, A. K., Edwards, S. J.
core   +1 more source