Results 91 to 100 of about 3,091,102 (249)
Fault Identification Method of Ball Bearing Based on IAs and SVMs
MATEC Web of Conferences, 2016 In order to effectively identify the bearing running condition, this paper proposed a new method which combines local mean decomposition (LMD) and support vector machine (SVM) together for ball bearing fault identification.
Chen Chao +5 more
doaj +1 more source
A Novel Rolling Bearing Fault Diagnosis and Severity Analysis Method
Applied Sciences, 2019 To improve the fault identification accuracy of rolling bearing and effectively analyze the fault severity, a novel rolling bearing fault diagnosis and severity analysis method based on the fast sample entropy, the wavelet packet energy entropy, and a ...
Yinsheng Chen +3 more
doaj +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
A novel directional pilot protection method for EHV transmission lines based on S-transform and SVM
Discover Applied SciencesTo address the issues of insufficient reliability and low sensitivity of traveling-wave (TW)-based protection caused by fault condition attributes, i.e., fault resistance and fault angle, this paper proposes a novel directional pilot protection method ...
Zhenwei Guo +3 more
doaj +1 more source
Adaptive fault identification for a class of nonlinear dynamic systems
, 2014 This paper is concerned with the diagnosis problem of actuator faults for a class of nonlinear systems. It is assumed that the upper bound of the Lipschtiz constant of the nonlinearity in the faulty system is unknown.
Ye D(叶丹) +2 more
core
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source