Results 101 to 110 of about 65,597 (292)

Teager–Kaiser Energy Operator-Based Short-Circuit Fault Localization Method for Multi-Circuit Parallel Cables

open access: yesEnergies
Medium-voltage cables in hydropower plants are typically arranged in multi-circuit configurations to ensure reliability, yet their exposure to harsh operational conditions accelerates insulation degradation and increases partial discharge risks ...
Zhichao Li   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Automated Fixing of Programs with Contracts

open access: yes, 2014
This paper describes AutoFix, an automatic debugging technique that can fix faults in general-purpose software. To provide high-quality fix suggestions and to enable automation of the whole debugging process, AutoFix relies on the presence of simple ...
Furia, Carlo A.   +5 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

A Method for Fault Localization in Distribution Networks with High Proportions of Distributed Generation Based on Graph Convolutional Networks

open access: yesEnergies
To address the issues arising from the integration of a high proportion of distributed generation (DG) into the distribution network, which has led to the transition from traditional single-source to multi-source distribution systems, resulting in ...
Xiping Ma   +5 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Efficient Fault Localization in Smart Grid Through Analysis of the Wave Matrix Image Using Convolutional Neural Networks

open access: yesIEEE Access
This article presents a methodology for fault localization in electric power distribution systems through the analysis of wave matrix image using Convolutional Neural Networks (CNN).
Jose Carlos Filho   +4 more
doaj   +1 more source

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