Results 121 to 130 of about 12,124 (305)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Fault location method for distribution networks based on multi-head graph attention networks

Frontiers in Energy Research
The precise fault localization holds significant importance in reducing power outage duration and frequency in power systems. The widespread application of synchrophasor measurement technology (PMU) has laid the foundation for achieving accurate fault ...
Lingyu Liang, Huanming Zhang, Shang Cao, Xiangyu Zhao, Hanju Li, Zhiwei Chen   +5 more
doaj   +1 more source

An Attention-Based Multidimensional Fault Information Sharing Framework for Bearing Fault Diagnosis

Deep learning has performed well in feature extraction and pattern recognition and has been widely studied in the field of fault diagnosis. However, in practical engineering applications, the lack of sample size limits the potential of deep learning in ...
Yizong Zhang, Xudong Yang, Hai Yang, Yunjin Hu, Qingsheng Xie   +4 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Mechanical Fault Sound Source Localization Estimation in a Multisource Strong Reverberation Environment

Shock and Vibration
Aiming at the sound source localization of mechanical faults in a strong reverberation scenario with multiple sound sources, this paper investigates a mechanical fault source localization method using the U-net deep convolutional neural network.
Yaohua Deng, Xiali Liu, Zilin Zhang, Daolong Zeng   +3 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Program structure aware fault localization

, 2014
Software testing is always an effective method to show the presence of bugs in programs, while debugging is never an easy task to remove a bug from a program in software development.
Heng Li, Yuzhen Liu, Liu, Jian, Liu, Y., Zhenyu Zhang, Li, H., Jian Liu, Zhang, Z.   +7 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

New Fault Diagnosis Strategy Based on KGLRT Chart for Monitoring Chemical Processes

Applied Sciences
Process monitoring methods play a crucial role in identifying equipment malfunctions and instrument failures, as well as in maintaining process safety and product quality. Selecting the right approach for fault detection and diagnosis is therefore vital.
Hajer Lahdhiri, Imen Hamrouni, Okba Taouali, Ali Alshehri, Esam Aloufi   +4 more
doaj   +1 more source