Results 121 to 130 of about 65,597 (292)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Mechanical Fault Sound Source Localization Estimation in a Multisource Strong Reverberation Environment

Shock and Vibration
Aiming at the sound source localization of mechanical faults in a strong reverberation scenario with multiple sound sources, this paper investigates a mechanical fault source localization method using the U-net deep convolutional neural network.
Yaohua Deng, Xiali Liu, Zilin Zhang, Daolong Zeng   +3 more
doaj   +1 more source

Fault location method for distribution networks based on multi-head graph attention networks

Frontiers in Energy Research
The precise fault localization holds significant importance in reducing power outage duration and frequency in power systems. The widespread application of synchrophasor measurement technology (PMU) has laid the foundation for achieving accurate fault ...
Lingyu Liang, Huanming Zhang, Shang Cao, Xiangyu Zhao, Hanju Li, Zhiwei Chen   +5 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

New Fault Diagnosis Strategy Based on KGLRT Chart for Monitoring Chemical Processes

Applied Sciences
Process monitoring methods play a crucial role in identifying equipment malfunctions and instrument failures, as well as in maintaining process safety and product quality. Selecting the right approach for fault detection and diagnosis is therefore vital.
Hajer Lahdhiri, Imen Hamrouni, Okba Taouali, Ali Alshehri, Esam Aloufi   +4 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Simple Fault Localization Using Execution Traces

2025 IEEE/ACM International Workshop on Automated Program Repair (APR)
Traditional spectrum-based fault localization (SBFL) exploits differences in a program's coverage spectrum when run on passing and failing test cases. However, such runs can provide a wealth of additional information beyond mere coverage. Working with thousands of execution traces of short programs submitted to competitive programming contests and ...
Prenner, Julian Aron, Robbes, Romain
openaire   +2 more sources

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source