Results 91 to 100 of about 538,374 (350)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Tectonic Landform and Lithologic Age Impact Uncertainties in Fault Displacement Hazard Models

Geophysical Research Letters
Tectonic landforms and surficial lithologic age are essential data for producing quality late Quaternary fault maps and predicting coseismic fault rupture location before an earthquake.
Chelsea Scott, Albert Kottke, Christopher Madugo, J. Ramon Arrowsmith, Rachel Adam, Malinda Zuckerman   +5 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Fault Location Method for Secondary System of Smart Substations Based on Network Flow Algorithm and Deep Neural Network

Zhongguo dianli
The existing intelligent substation secondary system fault location method relies on specific types of fault feature quantities, lacking the ability toively process multiple fault types.
Jun TAO, Ming ZHONG, Yi ZHANG, Feng LIU, Yuzhu WU, Zhenxing XIA   +5 more
doaj   +1 more source

Lattialämmitys, vianetsintä ja korjausmenetelmä [PDF]

, 2015
Tämän opinnäytetyön tarkoituksena oli tutkia, millaisilla keinoilla vikaantunut lämmityskaapeli pystyt-täisiin paikantamaan sekä korjaamaan. Työssä käsiteltiin lattialämmityskaapeleita, lämmityksen mitoit-tamista, vikatilanteita, vianpaikannuslaitteita ...
Hirvonen, Kai-Markus
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Fault MLReal: A fault delineation study for the Decatur CO₂ field data using neural network predicted passive seismic locations

, 2023
Hanchen Wang, Youzuo Lin, Yinpeng Chen, Tariq Alkhalifah   +3 more
openalex   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

An Improved Methodology to Locate Faults in Onshore Wind Farm Collector Systems

Energies
This paper explores the growing integration of Inverter-Based Resources (IBRs) into power systems and their effects on fault diagnosis strategies. Notably, the technical literature lacks assessments of the impacts and proposals for solutions for phasor ...
Moisés Davi, Alailton Júnior, Caio Grilo, Talita Cunha, Leonardo Lessa, Mário Oleskovicz, Denis Coury   +6 more
doaj   +1 more source