Results 41 to 50 of about 13,286 (264)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

How to incorporate human failure event recovery into minimal cut set generation stage for efficient probabilistic safety assessments of nuclear power plants

Nuclear Engineering and Technology, 2022
Human failure event (HFE) dependency analysis is a part of human reliability analysis (HRA). For efficient HFE dependency analysis, a maximum number of minimal cut sets (MCSs) that have HFE combinations are generated from the fault trees for the ...
Woo Sik Jung, Seong Kyu Park, John E. Weglian, Jeff Riley   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A Checkpoint and Recovery Facility for the Fault-Tolerant Process on Linux Environment

The KIPS Transactions:PartA, 2004
In this paper, we suggest a checkpoint and recovery facility for the fault-tolerable process which is expected to be executed for a long time. The basic concept of the suggested facility is to allow the process to be executed continuously, when the process was stopped due to a System fault, by storing the execution status of the process periodically ...
Seong-Rak Rim, Sin-Ho Kim
openaire   +2 more sources

Dynamic active torque coordination strategy for torsional vibration suppression in wind turbines during grid fault recovery

International Journal of Electrical Power & Energy Systems
When the grid fault occurs, wind turbines are required to possess fault ride-through (FRT) capability and rapidly restore active power after fault clearance.
Cai Guang, Yan Xiangwu, Zhang Shurui, Ren Haoyang, Jia Jiaoxin, Zhou Fan   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A Comprehensive Benchmarking Analysis of Fault Recovery in Stream Processing Frameworks

Proceedings of the 18th ACM International Conference on Distributed and Event-based Systems
Nowadays, several software systems rely on stream processing architectures to deliver scalable performance and handle large volumes of data in near real-time. Stream processing frameworks facilitate scalable computing by distributing the application's execution across multiple machines.
Vogel, Adriano, Henning, Sören, Perez-Wohlfeil, Esteban, Ertl, Otmar, Rabiser, Rick   +4 more
openaire   +3 more sources

Nowhere to Hide Methodology: Application of Clustering Fault Diagnosis in the Nuclear Power Industry

IEEE Access, 2019
When a system crashes, fast and accurate log-based fault diagnosis can remarkably reduce the recovery time of the system and avoid further economic losses. Especially for the nuclear power industry, recovery time will lead not only to economic losses but
Cheng Zong, Song Huang, Erhu Liu, Yongming Yao, Shi-Qi Tang   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Experimental and theoretical study on static recrystallization of a low-density ferritic steel containing 4 mass% aluminum

Materials & Design, 2019
The static recrystallization behavior of a low-density δ-ferritic steel containing 4 wt% Al was investigated by means of hot compression tests. The fractional softening obtained from the interrupted hot compression tests was used as a measure of the ...
Xiangyu Xu, Jianzhe Li, Weijie Li, Qiannan Liu, Dan Liu, Xuemin Wang, Jingliang Wang, Chengjia Shang, R.D.K. Misra   +8 more
doaj   +1 more source