Results 51 to 60 of about 14,064 (255)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Investigating the effects of fault reactivation and CO2 migration during combined CO2-EOR and sequestration within a mature oil reservoir

Journal of Petroleum Exploration and Production Technology, 2020
The investigation into the combined processes of CO2-EOR and geologic carbon sequestration was seen to be a viable solution to reducing CO2 emissions from the atmosphere, while boosting production from mature oil fields.
Shawn Pulchan, David Alexander, Donnie Boodlal   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Experimental and theoretical study on static recrystallization of a low-density ferritic steel containing 4 mass% aluminum

Materials & Design, 2019
The static recrystallization behavior of a low-density δ-ferritic steel containing 4 wt% Al was investigated by means of hot compression tests. The fractional softening obtained from the interrupted hot compression tests was used as a measure of the ...
Xiangyu Xu, Jianzhe Li, Weijie Li, Qiannan Liu, Dan Liu, Xuemin Wang, Jingliang Wang, Chengjia Shang, R.D.K. Misra   +8 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Research on fault self-healing strategy of a distribution network considering wind and solar accommodation capacity

Frontiers in Energy Research
As a traditional fault recovery strategy, network reconfiguration changes the structure of a distribution network by changing the switching state to achieve a normal power supply for non-fault power loss.
Lin Jiang, Canbin Wang, Chen Li, Caili Xiang   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Asynchronous Injection-Production Process: A Method to Improve Water Flooding Recovery in Complex Fault Block Reservoirs

Mathematical Problems in Engineering, 2020
The complex fault block reservoir has the characteristics of small area and many layers in vertical. Due to the influence of formation heterogeneity and well pattern, the situation that “water fingering is serious with water injection, on the contrary, driving energy is low” frequently occurs in water flooding, which makes it difficult to enhance oil ...
Shibao Yuan, Rui Wang, Haiyan Jiang, Qing Xie, Shengnan Chen, Bo Xu, Lehong Li, Yupeng Zhang   +7 more
openaire   +2 more sources