Results 61 to 70 of about 14,064 (255)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

The Identification of Fault Pattern Fractals for Improved Oil and Gas Recovery: A New Process to Identify and Describe Fault Sets Using Non-Linear Methods

Energy Exploration & Exploitation, 1992
Unexpected faults are a serious production problem in numerous, complex and compartmentalised oil and gas fields, and are often the single most important restraint on recovery. Fractal mathematics has demonstrated a surprising degree of order in many natural, apparently random systems. It has been shown that fault patterns exhibit a similar order which
Steve Kaye, Hans-Henrik Stolum
openaire   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Dynamic Multi-Robot Task Allocation for Human-in-the-Loop Space Exploration: Knowledge Graph-Guided CBBA with LLM-Assisted Fault Analysis

Machines
In dynamic and extreme space environments, current multi-robot systems inevitably encounter failures during autonomous task execution. Addressing these failures requires human-in-the-loop collaboration with astronauts, who first conduct fault analysis ...
Hao Wang, Shuqi Xue, Hongbo Zhang, Lifen Tan, Chunhui Wang, Yan Fu   +5 more
doaj   +1 more source

An Active Fault-Tolerant PWM Tracker for Unknown Nonlinear Stochastic Hybrid Systems: NARMAX Model and OKID-Based State-Space Self-Tuning Control

Journal of Control Science and Engineering, 2010
An active fault-tolerant pulse-width-modulated tracker using the nonlinear autoregressive moving average with exogenous inputs model-based state-space self-tuning control is proposed for continuous-time multivariable nonlinear stochastic systems with ...
Chu-Tong Wang, Jason S. H. Tsai, Chia-Wei Chen, You Lin, Shu-Mei Guo, Leang-San Shieh   +5 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Research on abnormal detection of transmission lines in high-risk areas on the distribution network side under extreme weather conditions

Journal of Applied Science and Engineering
This paper presents an integrated electric-gas energy system fault recovery method based on bidirectional coupled devices. Simulation examples of an IEEE 13-node electric system and a 6-node natural gas system are used to validate the effectiveness of ...
Anjiang Liu, Youzhuo Zheng, Di Weng, Hengrong Zhang, Xinhao Li   +4 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source