Results 71 to 80 of about 2,100,160 (252)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Number (%) of participants with favourable /unfavourable outcome in each Frenchay Activities Index (FAI) domain at six years after stroke.

, 2015
Number (%) of participants with favourable /unfavourable outcome in each Frenchay Activities Index (FAI) domain at six years after stroke.
Kerstin Tham (835373), Avvai Singam (835371), Charlotte Ytterberg (835372), Lena von Koch (34412)   +3 more
core   +1 more source

Favourable outcome after 26 minutes of "Compression only" resuscitation: a case report

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2010
Case presentation A 49 year old man had ventricular fibrillation in his home, at room temperature, due to an ST-elevation myocardial infarction. He received Cardiac compression only resuscitation (CC-only) for 26 minutes by his wife, followed by four ...
Steen-Hansen Jon
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Contemporary outcome measures in acute stroke research: choice of primary outcome measure [PDF]

, 2012
BACKGROUND AND PURPOSE: The diversity of available outcome measures for acute stroke trials is challenging and implies that the scales may be imperfect.
D. m. Kerr, R. Fulton, Matchar, D., D. Matchar, K. r. Lees, Schellinger, P., Bath, P.M.W., P. m. w. Bath, Lees, K.R., Kerr, D.M., Toni, D., TONI, Danilo, Sehra, R., R. Sehra, Hacke, W., P. d. Schellinger, Fulton, R., W. Hacke, Hacke, Werner, European Stroke Organization Outcomes Working Group, Kerr, Daniel M, Fulton, Rachael, Matchar, David, Schellinger, Peter D, Sehra, Ruchir, Bath, Philip MW, Lees, Kennedy R   +26 more
core   +1 more source

Benefits of adding a physician-staffed ambulance to bystander-witnessed out-of-hospital cardiac arrest: a community-based, observational study in Niigata, Japan

BMJ Open, 2019
Objective This study aimed to assess the benefits of adding a physician-staffed ambulance to bystander-witnessed out-of-hospital cardiac arrest using a community-based registry.Design Population-based, retrospective cohort study.Setting An urban city ...
Tasuku Matsuyama, Nobuhiro Sato, Kohei Akazawa, Kyoko Nakazawa, Yasuo Hirose   +4 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Prehospital cardiopulmonary resuscitation duration and neurological outcome after out-of-hospital cardiac arrest among children by location of arrest: a Nationwide cohort study

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2019
Background Little is known about the associations between the duration of prehospital cardiopulmonary resuscitation (CPR) by emergency medical services (EMS) and outcomes among paediatric patients with out-of-hospital cardiac arrests (OHCAs).
Haruka Shida, Tasuku Matsuyama, Kosuke Kiyohara, Tetsuhisa Kitamura, Takefumi Kishimori, Takeyuki Kiguchi, Chika Nishiyama, Daisuke Kobayashi, Satoe Okabayashi, Tomonari Shimamoto, Takashi Kawamura, Taku Iwami   +11 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source