Results 71 to 80 of about 496,947 (301)

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Using the prototype willingness model to predict doping in sport. [PDF]

, 2014
To enable preventive measures to be designed, it is important to identify modifiable distal and proximal factors underlying doping behavior. This study investigated aspects of the prototype willingness model in relation to doping. A cross-sectional study
Ajzen, Andrews, Backhouse, Blanton, Bloodworth, Fahey, Gibbons, Gibbons, Goulet, Hasking, Hauw, Kirby, Kondric, Kreuter, Lazuras, Lentillon-Kaestner, Lucidi, Mazanov, Melzer, Nulty, Petróczi, Petróczi, Petróczi, Pitsch, Pomery, Rivis, Tabachnick, Thornton, UNESCO, Uvacsek, WADA, Whitaker, Wiefferink, Zimmermann   +33 more
core   +1 more source

Effects of the Fluid Replacement Method During Online Hemodiafiltration on the Solute Removal Performance and Biocompatibility Using the Asymmetric Cellulose Triacetate Membrane

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai, Yoshitaka Kurihara, Fumi Yamauchi, Hiromi Hosoya, Takeshi Saito   +4 more
wiley   +1 more source

Pathogenetically Substantiated Therapy of Patients with Virus Hepatitis C, the Life Quality and the Disease Outcome Risk (Clinical Survey)

Антибиотики и Химиотерапия, 2020
The aspects of virus hepatitis C immunopathogenesis are discussed. The main attention is paid to higher production of Th1 cytokines providing active protection of the host from HCV.
M. G. Romantsov, T. V. Sologub, L. G. Goryacheva, S. N. Kovalenko, D. S. Sukhanov, A. A. Shuldyakov, A. N. Bondarenko, A. L. Kovalenko, A. YU. Petrov   +8 more
doaj  

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Favourable outcome after 26 minutes of "Compression only" resuscitation: a case report

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2010
Case presentation A 49 year old man had ventricular fibrillation in his home, at room temperature, due to an ST-elevation myocardial infarction. He received Cardiac compression only resuscitation (CC-only) for 26 minutes by his wife, followed by four ...
Steen-Hansen Jon
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Benefits of adding a physician-staffed ambulance to bystander-witnessed out-of-hospital cardiac arrest: a community-based, observational study in Niigata, Japan

BMJ Open, 2019
Objective This study aimed to assess the benefits of adding a physician-staffed ambulance to bystander-witnessed out-of-hospital cardiac arrest using a community-based registry.Design Population-based, retrospective cohort study.Setting An urban city ...
Tasuku Matsuyama, Nobuhiro Sato, Kohei Akazawa, Kyoko Nakazawa, Yasuo Hirose   +4 more
doaj   +1 more source

Adiponectin expression in patients with inflammatory cardiomyopathy indicates favourable outcome and inflammation control [PDF]

, 2017
Aims Circulating adiponectin (APN) is an immunomodulatory, pro-angiogenic, and anti-apoptotic adipocytokine protecting against acute viral heart disease and preventing pathological remodelling after cardiac injury.
Bobbert, Peter, Eriksson, Urs, Jenke, Alexander, Kania, Gabriele, Krohn, Stefanie, Kuehl, Uwe, Poller, Wolfgang, Rauch, Ursula, Scheibenbogen, Carmen, Schultheiss, Heinz Peter, Skurk, Carsten, Stehr, Jenny, Wilk, Sabrina   +12 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source