Results 61 to 70 of about 2,100,160 (252)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Multivariate analysis for predictors of favourable and unfavourable treatment outcome among 493^¶ pulmonary tuberculosis patients.

, 2018
Multivariate analysis for predictors of favourable and unfavourable treatment outcome among 493¶ pulmonary tuberculosis patients.
Fatima Mukhtar (5946605), Zahid A. Butt (3287055)   +1 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Predictors of favourable outcome in young people with a first episode psychosis without antipsychotic medication.

, 2017
Data from the literature suggests that some first episode psychosis (FEP) patients may recover without antipsychotic medication. There is however no reliable way to identify them.
O'Donoghue, B., Schimmelmann, B.G., Cotton, S.M., Lambert, M., McGorry, P.D., Francey, S.M., Conus, P.   +6 more
core   +1 more source

Apolipoprotein E polymorphism and neuropsychological outcome following subarachnoid haemorrhage [PDF]

, 2004
Objectives–To investigate the association between APOE genotype and cognitive and emotional outcome following spontaneous subarachnoid haemorrhage (SAH).Materials and methods–Neuropsychological assessments were conducted with 70 SAH survivors derived ...
Morris, Paul Graham; id_orcid, Nicoll, James A R, Dunn, L.T., Wilson, J T Lindsay, Dunn, Laurence T, Nicoll, J.A., Wilson, J.T., Morris, P.G.   +7 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Functional outcome of patients with spinal cord injury: rehabilitation outcome study [PDF]

, 1999
Objective: To increase our knowledge of neurological recovery and functional outcome of patients with spinal cord injuries in order to make more successful rehabilitation programmes based on realistic goals.Design: Descriptive analysis of data gathered ...
Mulder, G.A., Schönherr, M.C., Groothoff, J.W., Eisma, W.H.   +3 more
core   +1 more source

Effect of intra-arrest trans-nasal evaporative cooling in out-of-hospital cardiac arrest: a pooled individual participant data analysis

Critical Care, 2021
Background Randomized trials have shown that trans-nasal evaporative cooling initiated during CPR (i.e. intra-arrest) effectively lower core body temperature in out-of-hospital cardiac arrest patients.
Fabio Silvio Taccone, Jacob Hollenberg, Sune Forsberg, Anatolij Truhlar, Martin Jonsson, Filippo Annoni, Dan Gryth, Mattias Ringh, Jerome Cuny, Hans-Jörg Busch, Jean-Louis Vincent, Leif Svensson, Per Nordberg, PRINCE, PRINCESS investigators   +14 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Pathogenetically Substantiated Therapy of Patients with Virus Hepatitis C, the Life Quality and the Disease Outcome Risk (Clinical Survey)

Антибиотики и Химиотерапия, 2020
The aspects of virus hepatitis C immunopathogenesis are discussed. The main attention is paid to higher production of Th1 cytokines providing active protection of the host from HCV.
M. G. Romantsov, T. V. Sologub, L. G. Goryacheva, S. N. Kovalenko, D. S. Sukhanov, A. A. Shuldyakov, A. N. Bondarenko, A. L. Kovalenko, A. YU. Petrov   +8 more
doaj