Results 31 to 40 of about 4,372 (178)

Environmental Mycotoxins and Brain Health: Protective Role of Bromelain Against Fumonisin B1 in SH‐SY5Y Cells

Environmental Toxicology, EarlyView.
ABSTRACT Fumonisin B1 (FB1), a mycotoxin commonly found in contaminated food and feed, has been increasingly implicated in neurotoxicity, although its mechanisms remain poorly understood. This study investigates the neurotoxic potential of FB1 in human SH‐SY5Y neuroblastoma cells, both undifferentiated and RA‐differentiated, and evaluates the ...
Gianluca Antonio Franco, Francesca Inferrera, Nicla Tranchida, Davide Di Paola, Roberta Fusco, Salvatore Cuzzocrea, Enrico Gugliandolo   +6 more
wiley   +1 more source

Effect of Surface Charge on the Interfacial Orientation and Conformation of FB1 in Model Membranes

The Journal of Physical Chemistry B, 2012
The toxicity of FB1 is usually explained through the enzymatic disruption of lipidic metabolism. However, it may lie in the thermodynamics of the membrane and its cooperative phase behavior rather than in the activity of individual proteins. Here, we investigate the effects of FB1 at the molecular and mesoscopic levels in FB1-phospholipid mixed ...
Theumer, Martín Gustavo, Clop, Pedro Diego, Rubinstein, Héctor Ramón, Perillo, Maria Angelica   +3 more
openaire   +3 more sources

Electrochemical aptasensors for ultrasensitive multiplexed detection: Towards a new era of precision diagnostics and environmental monitoring

VIEW, EarlyView.
Electrochemical aptasensors are emerging as powerful platforms for precision diagnostics and environmental monitoring, owing to their high selectivity, programmability and compatibility with miniaturised systems. However, their broader application is constrained by limited signal intensity and challenges in reliable multiplexed detection.
Azadeh Abdi, Ngoan Thi Thao Nguyen, Riccardo Zulli, Jacopo Giaretta, Fariba Dehghani, Syamak Farajikhah   +5 more
wiley   +1 more source

Toxic effects of palmitoyl-, oleoyl-, and linoleoyl-fumonisin B1 derivatives on zebrafish embryos and their interactions with serum albumin

Emerging Contaminants
Acyl derivatives of the mycotoxin fumonisin B1 (FB1) occur in naturally infected grains and can be formed during certain food processing steps and/or as in vivo metabolites of the parent mycotoxin.
Zsolt Csenki, Illés Bock, Levente Horváth, Artur Stepniak, Béla Fiser, Adam Buczkowski, Gergő Tóth, Dávid Csabai, Dávid Hesszenberger, Anikó Lajtai, Sándor Kunsági-Máté, Melinda Kovács, István Szabó, Balázs Kriszt, Tibor Bartók, Miklós Poór   +15 more
doaj   +1 more source

Public understandings of self‐defence claims by domestic abuse victim‐survivors

Journal of Law and Society, EarlyView.
Abstract This article explores public understandings of self‐defence claims in fatal and non‐fatal domestic abuse cases. The topic is of contemporary interest following the government's rejection of proposals to introduce a bespoke defence for domestic abuse victims who use force against their abusers based on the inaccurate claim that the defence of ...
VANESSA BETTINSON, NICOLA WAKE, THOMAS CROFTS   +2 more
wiley   +1 more source

Application of Fish Industry Waste in the Removal of Mycotoxin FB1

The eurobiotech journal, 2023
This research focuses on exploring the potential of sea bass and sea bream bones and scales as biological adsorbents for binding Fumonisin B1(FB1), a toxic mycotoxin prevalent in corn and corn products used in poultry feed. Mycotoxins are harmful byproducts produced by molds, posing significant health risks to humans.
Kostelac, Deni, Čanak, Iva, Frece, Jadranka, Markov, Ksenija, Ivešić, Martina, Pavlek, Željka, Jakopović, Željko   +6 more
openaire  

More of the Same: A Document Analysis of the Government's Response to Ageing with Intellectual Disabilities in Hong Kong

Journal of Policy and Practice in Intellectual Disabilities, Volume 23, Issue 3, September 2026.
ABSTRACT As the population of people ageing with intellectual disabilities grew in the 1980s, the Hong Kong government supported research exploring their needs and recommended a range of initiatives, including the promotion of community inclusion. This study aimed to identify how the government has understood and responded to the ‘problem’ of people ...
Kangwei Xun, Christine Bigby, Tal Araten‐Bergman   +2 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, Volume 20, Issue 7, Page 1877-1888, July 2026.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Involvement of Autophagy and Oxidative Stress-Mediated DNA Hypomethylation in Transgenerational Nephrotoxicity Induced in Rats by the Mycotoxin Fumonisin B1

Toxins, 2023
Fumonisin B1 (FB1), a mycotoxin produced by Fusarium verticillioides, is one of the most common pollutants in natural foods and agricultural crops. It can cause chronic and severe health issues in humans and animals. The aim of this study was to evaluate
Nouf Aldawood, Sarah Almustafa, Saleh Alwasel, Waleed Aldahmash, Abir Ben Bacha, Abdullah Alamri, Mohammad Alanazi, Abdel Halim Harrath   +7 more
doaj   +1 more source

Co‐Detoxification of Multiple Mycotoxins: Microbial and Enzymatic Biodegradation Processes

Food Frontiers, Volume 7, Issue 4, July 2026.
The presence of mycotoxins poses a threat to food safety. This article reviews microbial/enzymatic detoxification technologies and the main degradation pathways of key mycotoxins. We propose to overcome current bottlenecks through enzyme engineering and synthetic biology, providing a roadmap for sustainable and scalable solutions.
Lixia Fan, Changying Guo, Saranya Poapolathep, Amnart Poapolathep, Mingxiao Ning, Bingchun Zhang, Xianfeng Ren, Antonio F. Logrieco   +7 more
wiley   +1 more source