Results 21 to 30 of about 153,756 (258)

Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21

eLife, 2018
Cell surface Fc receptors activate inflammation and are tightly controlled to prevent autoimmunity. Antibodies also simulate potent immune signalling from inside the cell via the cytosolic antibody receptor TRIM21, but how this is regulated is unknown ...
Claire Dickson, Adam J Fletcher, Marina Vaysburd, Ji-Chun Yang, Donna L Mallery, Jingwei Zeng, Christopher M Johnson, Stephen H McLaughlin, Mark Skehel, Sarah Maslen, James Cruickshank, Nicolas Huguenin-Dezot, Jason W Chin, David Neuhaus, Leo C James   +14 more
doaj   +1 more source

On the complexity of IgE: The role of structural flexibility and glycosylation for binding its receptors

Frontiers in Allergy, 2023
It is well established that immunoglobulin E (IgE) plays a crucial role in atopy by binding to two types of Fcε receptors (FcεRI and FcεRII, also known as CD23).
Kevin Plattner, Kevin Plattner, Martin F. Bachmann, Martin F. Bachmann, Martin F. Bachmann, Monique Vogel, Monique Vogel   +6 more
doaj   +1 more source

IgE Antibodies: From Structure to Function and Clinical Translation

Antibodies, 2019
Immunoglobulin E (IgE) antibodies are well known for their role in mediating allergic reactions, and their powerful effector functions activated through binding to Fc receptors FcεRI and FcεRII/CD23. Structural studies of IgE-Fc alone, and when
Brian J. Sutton, Anna M. Davies, Heather J. Bax, Sophia N. Karagiannis   +3 more
doaj   +1 more source

Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination

Cell Reports Medicine, 2021
Summary: Recently approved vaccines have shown remarkable efficacy in limiting SARS-CoV-2-associated disease. However, with the variety of vaccines, immunization strategies, and waning antibody titers, defining the correlates of immunity across a ...
Matthew J. Gorman, Nita Patel, Mimi Guebre-Xabier, Alex L. Zhu, Caroline Atyeo, Krista M. Pullen, Carolin Loos, Yenny Goez-Gazi, Ricardo Carrion, Jr., Jing-Hui Tian, Dansu Yuan, Kathryn A. Bowman, Bin Zhou, Sonia Maciejewski, Marisa E. McGrath, James Logue, Matthew B. Frieman, David Montefiori, Colin Mann, Sharon Schendel, Fatima Amanat, Florian Krammer, Erica Ollmann Saphire, Douglas A. Lauffenburger, Ann M. Greene, Alyse D. Portnoff, Michael J. Massare, Larry Ellingsworth, Gregory Glenn, Gale Smith, Galit Alter   +30 more
doaj   +1 more source

Fc Binding by FcγRIIa Is Essential for Cellular Activation by the Anti-FcγRIIa mAbs 8.26 and 8.2

Frontiers in Immunology, 2021
FcγR activity underpins the role of antibodies in both protective immunity and auto-immunity and importantly, the therapeutic activity of many monoclonal antibody therapies.
Bruce D. Wines, Bruce D. Wines, Bruce D. Wines, Halina M. Trist, Sandra Esparon, Rachael E. Impey, Graham A. Mackay, Robert K. Andrews, Tatiana P. Soares da Costa, Geoffrey A. Pietersz, Geoffrey A. Pietersz, Ross I. Baker, Ross I. Baker, P. Mark Hogarth, P. Mark Hogarth, P. Mark Hogarth   +15 more
doaj   +1 more source

QTY Code-designed Water-soluble Fc-fusion Cytokine Receptors Bind to their Respective Ligands

QRB Discovery, 2020
Cytokine release syndrome (CRS), or ‘cytokine storm’, is the leading side effect during chimeric antigen receptor (CAR)-T therapy that is potentially life-threatening.
Shilei Hao, David Jin, Shuguang Zhang, Rui Qing   +3 more
doaj   +1 more source

Expression and Display of Glycoengineered Antibodies and Antibody Fragments with an Engineered Yeast Strain

Antibodies, 2021
Interactions with cell surface receptors enhance the therapeutic properties of many important antibodies, including the low-affinity Fc γ Receptors (FcγRs). These interactions require proper processing of the immunoglobulin G Fc N-glycan, and eliminating
Anjali Shenoy, Srisaimaneesh Yalamanchili, Alexander R. Davis, Adam W. Barb   +3 more
doaj   +1 more source

The pharmacology and therapeutic applications of monoclonal antibodies

Pharmacology Research & Perspectives, 2019
Monoclonal antibodies (mAbs) have emerged as a major class of therapeutic agents on the market. To date, approximately 80 mAbs have been granted marketing approval.
María Sofía Castelli, Paul McGonigle, Pamela J. Hornby   +2 more
doaj   +1 more source

Human cytomegalovirus antagonizes activation of Fcγ receptors by distinct and synergizing modes of IgG manipulation

eLife, 2021
Human cytomegalovirus (HCMV) is endowed with multiple highly sophisticated immune evasion strategies. This includes the evasion from antibody mediated immune control by counteracting host Fc-gamma receptor (FcγR) mediated immune control mechanisms such ...
Philipp Kolb, Katja Hoffmann, Annika Sievert, Henrike Reinhard, Eva Merce-Maldonado, Vu Thuy Khanh Le-Trilling, Anne Halenius, Dominique Gütle, Hartmut Hengel   +8 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source