Results 161 to 170 of about 716,992 (304)

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran, Malo Gaubert, Alice Dufey, Elise Bannier, Audrey Rico, Jean‐Christophe Ferré, Raphaël Chouteau, Laure Michel, Emmanuelle Le Page, Virginie Callot, Bertrand Audoin, Sarah Demortière, Benoît Combès, Anne Kerbrat   +13 more
wiley   +1 more source

Fear Conditioning

, 2010
Joris C Verster, Thomas M. Tzschentke, Kieran O’Malley, Francis C Colpaert, Bart Ellenbroek, Bart Ellenbroek, R. Hamish McAllister-Williams, Joachim Liepert, Cecilia J. Hillard, Sheldon Preskorn, Megan M Dahmen, Janka Lincoln, Oliver Stiedl, Sven Ove Ögren, E C Warburton, Bernard Le Foll, Mohammed Shoaib, Victoria L Harvey, Tony Dickenson, Ennio Esposito, Roberto William Invernizzi, Ennio Esposito, Robert William Invernizzi, Edoardo Spina, Cyril Höschl, Kim Wolff, Andreas Marneros, Anthony L. Riley, Steve Kohut, Samuel R. Chamberlain, Barbara J. Sahakian, David C.S. Roberts, Joseph Zohar, Seiya Miyamoto, Malcolm Lader, Emma Childs, Lawrence H. Price, Harriet de Wit, Wolfgang Fleischhacker, Lance Richard McMahon, Bernard Le Foll, Bernard Le Foll, Lawrence H. Price, Kieran O’Malley, Kieran O’Malley, Stephen M. Stahl, Meghan M Grady, Stephen C Fowler, Francis C. Colpaert, Alex Hofer, Etienne Sibille, Nicole Edgar, Linda P. Spear, Sam Hutton, Linda Lundstroem, Silvia Gatti McArthur, Will Spooren, Maria Isabel Colado, Richard Green, Marcy J. Bubar, Kathryn A Cunningham, Stephan G. Anagnostaras, Jennifer R Sage, Stephanie A. Carmack, Peter H. Boeijinga, Peter H. Boeijinga, Paul Newhouse, Heather Wilkins, Gary Remington, John Atack, Hilde Lavreysen   +70 more
openaire   +3 more sources

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Model-Free and Model-Based Learning in Human Fear Conditioning. [PDF]

Psychophysiology
Stemerding LE, Gerlicher AMV, Reinhold FL, Kindt M.   +3 more
europepmc   +1 more source

Systematic constellations of neurons are activated in lateral amygdala following Pavlovian fear conditioning

, 2006
How memory is organized within neural networks is a fundamental question in neuroscience. We used Pavlovian fear conditioning to study the discrete organization patterns of neurons activated in an associative memory paradigm.
Little, Justin P., LeDoux, Joseph E., Haranhalli, Neil, Johnson, Luke R., Massie, Lara W.   +4 more
core  

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

A systematic review of spontaneous recovery in human fear conditioning. [PDF]

Front Behav Neurosci
Anderson J, Wang Y, Clark DL, Lipp OV, Jarvis M, Ney LJ.   +5 more
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Enhanced autonomic fear conditioning at age 3 in successful adult criminal offenders. [PDF]

Emotion
Raine A, Gao Y, Choy O.
europepmc   +1 more source