Results 61 to 70 of about 2,304,658 (297)
Frontiers in Molecular Neuroscience, 2018 The genetic and molecular basis underlying fear memory formation is a key theme in anxiety disorder research. Because activating transcription factor 3 (ATF3) is induced under stress conditions and is highly expressed in the hippocampus, we hypothesize ...
Chia-Sheng Pai +9 more
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Molecular Mechanisms of Fear Learning and Memory [PDF]
Cell, 2011 Pavlovian fear conditioning is a particularly useful behavioral paradigm for exploring the molecular mechanisms of learning and memory because a well-defined response to a specific environmental stimulus is produced through associative learning processes. Synaptic plasticity in the lateral nucleus of the amygdala (LA) underlies this form of associative
Johansen, Joshua P. +3 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
eLife, 2021 Emotional memory processing engages a large neuronal network of brain regions including the cerebellum. However, the molecular and cellular mechanisms of the cerebellar cortex modulating the fear memory network are unclear.
Jeong-Kyu Han +7 more
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Science, 2019 Neuroscience Treatment for anxiety and fear is often based on extinction training, but fear can spontaneously reappear even after successful initial treatment. Neuroscientists have discovered two different neuronal ensembles operating within the brain's hippocampal dentate gyrus: extinction neurons and fear engram neurons. Lacagnina et al.
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Ethanol Enhances Reactivated Fear Memories [PDF]
Neuropsychopharmacology, 2008 Although ethanol has been shown to impair acquisition of memory, its effect on consolidated memories is not clear. Recent reports revealed that memory retrieval converted consolidated memory into a labile state and initiated the reconsolidation process. In the present study, we have demonstrated the effect of ethanol on reactivated fear memory. We used
Hiroshi, Nomura, Norio, Matsuki
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FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
A novel form of memory for auditory fear conditioning at a low-intensity unconditioned stimulus. [PDF]
PLoS ONE, 2009 Fear is one of the most potent emotional experiences and is an adaptive component of response to potentially threatening stimuli. On the other hand, too much or inappropriate fear accounts for many common psychiatric problems.
Ayumi Kishioka +8 more
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Cell Reports, 2023 Summary: Overly strong fear memories can cause pathological conditions. Histamine H3 receptor (H3R) has been viewed as an optimal drug target for CNS disorders, but its role in fear memory remains elusive.
Yanrong Zheng +10 more
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The effect of distraction on fear reduction during In Vivo exposure for Spider-fearful individuals: Exploring the relationship between fear level and distraction load [PDF]
, 2012 Exposure-based therapy is currently the treatment of choice for a number of specific phobias (Antony & Barlow, 2002). While a myriad of studies have been conducted investigating exposure characteristics, such as frequency and duration, or comparing ...
Ellis, Samantha
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