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Diazepam blocks fear-potentiated startle in humans.
Journal of Abnormal Psychology, 1996The effects of an anxiolytic drug (diazepam) on emotional responses to aversive stimuli were investigated using physiological measures, including the startle probe reflex. Participants were 54 university students assigned to either a placebo group or a 10 mg or 15 mg diazepam group in a double-blind design.
C J, Patrick, B D, Berthot, J D, Moore
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The fear potentiated startle effect
Integrative Physiological and Behavioral Science, 1991A differential conditioning study examined whether an acoustic startle probe, presented during extinction of an aversively conditioned visual stimulus, potentiated the reflex eyeblink response in humans and whether this potentiation varied with the change in affective valence of the conditioned stimulus. Sixty college students were randomly assigned to
A O, Hamm +4 more
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Delayed development of fear-potentiated startle in rats.
Behavioral Neuroscience, 1994The developmental emergence of fear-potentiated startle was examined in rats ranging in age from 16 to 75 days. In Experiment 1, a pure tone served as the conditioned stimulus (CS) and an acoustic startle pulse served as the unconditioned stimulus (US) for fear conditioning.
Pamela S. Hunt +2 more
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A Single Administration of Testosterone Reduces Fear-Potentiated Startle in Humans
Biological Psychiatry, 2006Ample evidence from animal research indicates that the gonadal steroid hormone testosterone has fear-reducing properties. Human data on this topic, however, are scarce and far less unequivocal. The present study therefore aimed to scrutinize anxiolytic effects of a single dose of testosterone, using a direct physiological index of fear in humans.Twenty
Hermans, E.J. +4 more
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Conditioned inhibition of fear-potentiated startle and skin conductance in humans
Psychophysiology, 2001Conditioned inhibition of classical conditioning was investigated with the startle reflex and the skin conductance response (SCR) in humans using a serial presentation of the conditioned inhibitor (X) and of the conditioned stimulus (CS). The unconditioned stimulus (US) was a shock.
C, Grillon, R, Ameli
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Behavioral Neuroscience, 2000
Fear-potentiated startle was assessed in mice with a targeted disruption of the alpha and delta isoforms of the transcription factor cAMP response element binding protein (CREB) 24 hr after 5 tone + shock training trials. Whereas wild-type mice showed fear-potentiated startle that persisted up to 45 days after training, CREBalphadelta-/- mice failed to
W A, Falls +5 more
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Fear-potentiated startle was assessed in mice with a targeted disruption of the alpha and delta isoforms of the transcription factor cAMP response element binding protein (CREB) 24 hr after 5 tone + shock training trials. Whereas wild-type mice showed fear-potentiated startle that persisted up to 45 days after training, CREBalphadelta-/- mice failed to
W A, Falls +5 more
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Latent inhibition of fear potentiated startle in rats.
Behavioural pharmacology, 1999Non-reinforced pre-exposure to a prospective conditioned stimulus impairs subsequent conditioning. This phenomenon is termed latent inhibition. In this report, we demonstrate latent inhibition in a classical conditioning procedure, the fear-potentiated startle reflex.
C, Schauz, M, Koch
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Fear-Potentiated Startle Response in Mice
Pharmacology Biochemistry and Behavior, 2000James A. Mccaughran +2 more
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