Results 71 to 80 of about 483,021 (202)

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Fear-potentiated startle: a review from an aviation perspective

, 2015
Pilot performance following unexpected critical events has been either ineffective or inappropriate in some recent aircraft accidents. The deleterious effects of startle have been identified as causal or contributory in these events.
Lee, Paul S. Y., Bates, Paul R., Martin, Wayne L., Murray, Patrick S.   +3 more
core   +1 more source

Men Scare Me More: Gender Differences in Social Fear Conditioning in Virtual Reality

Frontiers in Psychology, 2019
Women nearly twice as often develop social anxiety disorder (SAD) compared to men. The reason for this difference is still being debated. The present study investigates gender differences and the effect of male versus female agents in low (LSA) and high ...
Jonas Reichenberger, Michael Pfaller, Diana Forster, Jennifer Gerczuk, Youssef Shiban, Andreas Mühlberger   +5 more
doaj   +1 more source

Combined administration of buntanetap and dulaglutide counteracts synaptic dysfunction and memory loss in an Alzheimer's disease mouse model

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 4, October/December 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) results from disruptions in proteostasis, metabolism, and neurotrophic signaling that impair synaptic plasticity and memory. Dulaglutide, a blood–brain barrier (BBB)‐permeant glucagon‐like peptide‐1 (GLP‐1) receptor agonist, enhances phosphoinositide 3‐kinase (PI3K)/Akt and cAMP response element‐binding ...
Erica Acquarone, Steve B. Garcia Gutierrez, Hong Zhang, Alexander Morin, Maria Maccecchini, Ottavio Arancio   +5 more
wiley   +1 more source

Contextual change after fear acquisition affects conditioned responding and the time course of extinction learning – Implications for renewal research

Frontiers in Behavioral Neuroscience, 2015
Context plays a central role in retrieving (fear) memories. Accordingly, context manipulations are inherent to most return of fear (ROF) paradigms (in particular renewal), involving contextual changes after fear extinction.
Rachel eSjouwerman, Johanna eNiehaus, Tina Barbara Lonsdorf   +2 more
doaj   +1 more source

Integrating novel therapeutic strategies in myeloproliferative neoplasms: Driving disease‐directed progress

British Journal of Haematology, Volume 209, Issue 4, Page 1450-1468, October 2026.
Summary Over the past decade, there has been a substantial increase in the diversity and number of therapeutic options for myeloproliferative neoplasms (MPNs). While many remain within the clinical trial arena, the clinician and patient community have seen more approvals reaching the clinic and a rethink on how best we should be approaching these ...
Trung Q. Ngo, Maria Georgiou, Donal P. McLornan, Claire N. Harrison   +3 more
wiley   +1 more source

Rethinking the Oligodendrocyte Progenitor Cell: One Cell, Many Functions

European Journal of Neuroscience, Volume 64, Issue 7, October 2026.
Oligodendrocyte progenitor cells (OPCs) are increasingly recognised as multifunctional CNS cells rather than mere precursors of myelinating oligodendrocytes. Alongside myelination and remyelination, they contribute to myelin and circuit plasticity, circuit regulation, vascular and blood–brain barrier regulation and neuroimmune modulation.
Alerie G. de la Fuente
wiley   +1 more source

BDNF-dependent consolidation of fear memories in the perirhinal cortex

Frontiers in Behavioral Neuroscience, 2013
In the recent years the perirhinal cortex (PRh) has been identified as a crucial brain area in fear learning. Since the neurotrophin BDNF (brain-derived neurotrophic factor) is an important mediator of synaptic plasticity and also crucially involved in ...
Brigitte eSchulz-Klaus, Volkmar eLessmann, Thomas eEndres   +2 more
doaj   +1 more source

Electrocortical and Physiological Correlates of Memory and Attention During the Anticipation of Avoidable and Inevitable Threats

Psychophysiology, Volume 63, Issue 10, October 2026.
ABSTRACT When confronted with danger, humans display a range of defensive behaviors, such as freezing and active avoidance. Prior research has identified a distinct physiological response pattern to avoidable threats, characterized by heart rate bradycardia, reduced visual exploration, and suppressed visual alpha activity (8–13 Hz), all of which are ...
Yannik Stegmann, Matthias Gamer
wiley   +1 more source

Olfactory bulbectomy does not affect conditioned inhibition of fear as measured with fear-potentiated startle

, 1999
The present study examined the effects of olfactory bulbectomy, an animal model of depression, on conditioned inhibition as measured with fear-potentiated startle, an animal model of anxiety.
Leal-Puente, Laura
core   +1 more source