Results 1 to 10 of about 9,243 (198)

High-Throughput mRNA Sequencing Reveals Potential Therapeutic Targets of Febuxostat in Secondary Injury After Intracerebral Hemorrhage

Frontiers in Pharmacology, 2022
Febuxostat is a urate-lowering medication for the treatment of patients with gout. This study was performed to elucidate the effects and underlying mechanisms of febuxostat on neuronal injury induced by intracerebral hemorrhage (ICH) in mice. The results
Xueyan Wang, Chenyu Zhang, Chenyu Zhang, Yuwen Li, Yuwen Li, Ting Xu, Ting Xu, Jin Xiang, Yang Bai, Ying Zhang, Qi Wang, Tiejun Zhang, Linchuan Liao   +12 more
doaj   +2 more sources

Combination of Panax ginseng C. A. Mey and Febuxostat Boasted Cardioprotective Effects Against Doxorubicin-Induced Acute Cardiotoxicity in Rats [PDF]

Frontiers in Pharmacology, 2022
Doxorubicin (DOX) is an anticancer agent for treating solid and soft tissue malignancies. However, the clinical use of DOX is restricted by cumulative, dose-dependent cardiotoxicity.
Hayder M. Al-Kuraishy, Hany A. Al-Hussaniy, Ali I. Al-Gareeb, Walaa A. Negm, Aya H. El-Kadem, Gaber El-Saber Batiha, Nermeen N. Welson, Gomaa Mostafa-Hedeab, Gomaa Mostafa-Hedeab, Ahmed H Qasem, Carlos Adam Conte-Junior   +10 more
doaj   +2 more sources

Cardiovascular Safety of Febuxostat and Allopurinol in Hyperuricemic Patients With or Without Gout: A Network Meta-Analysis

Frontiers in Medicine, 2021
Background: Hyperuricemia is a common metabolic disease and has become a public health problem because of its increasing prevalence and association with comorbidities.
Shengzhao Zhang, Shengzhao Zhang, Ting Xu, Ting Xu, Qingyang Shi, Sheyu Li, Sheyu Li, Ling Wang, Zhenmei An, Na Su, Na Su   +10 more
doaj   +2 more sources

Comparative efficacy and safety of febuxostat and allopurinol in chronic kidney disease stage 3–5 patients with asymptomatic hyperuricemia: a network meta-analysis [PDF]

Renal Failure
Objective This study evaluates and compares the effectiveness and safety of febuxostat and allopurinol in chronic kidney disease (CKD) stages 3–5 patients with asymptomatic hyperuricemia using a network meta-analysis.Methods A systematic review and ...
Jiaojiao Chen, Yanyun Zhang, Yinglin Wang, Lu Chen   +3 more
doaj   +2 more sources

Comparative assessment of the effects of dotinurad and febuxostat on the renal function in chronic kidney disease patients with hyperuricemia [PDF]

Scientific Reports
Although hyperuricemia is associated with chronic kidney disease (CKD), the impact of uric acid (UA)-lowering drugs on CKD has been controversial.
Tomoaki Takata, Sosuke Taniguchi, Yukari Mae, Kana Kageyama, Yudai Fujino, Takuji Iyama, Katsuya Hikita, Takaaki Sugihara, Hajime Isomoto   +8 more
doaj   +2 more sources

Changes in Uric Acid Levels and Effects on Renal Function After Switching From Febuxostat to Dotinurad in Patients With Chronic Kidney Disease: A Retrospective Study [PDF]

Cureus
Mima A, Matsumoto K, Matsuki T, Morikawa T, Kure S, Akai R, Saito Y, Lee S.   +7 more
europepmc   +3 more sources

Efficacy and safety of febuxostat in elderly female patients

Clinical Interventions in Aging, 2014
Tomohiro Mizuno,1,2 Takahiro Hayashi,3 Sayo Hikosaka,1 Yuka Shimabukuro,1 Maho Murase,1 Kazuo Takahashi,2 Hiroki Hayashi,2 Yukio Yuzawa,2 Tadashi Nagamatsu,1 Shigeki Yamada3 1Department of Analytical Pharmacology, Graduate School of Pharmacy, Meijo ...
Mizuno T, Hayashi T, Hikosaka S, Shimabukuro Y, Murase M, Takahashi K, Hayashi H, Yuzawa Y, Nagamatsu T, Yamada S   +9 more
doaj   +1 more source

Febuxostat-Induced Agranulocytosis: An Illustrative Case Report and Comprehensive Literature Review. [PDF]

Clin Case Rep
Liu Q, Zhong B.
europepmc   +3 more sources

A single-centre experience of febuxostat as a second-line urate-lowering therapy [PDF]

Malaysian Family Physician, 2021
Introduction: The purpose of this study was to describe the local experience in terms of drug efficacy and safety using a new xanthine oxidase inhibitor, febuxostat, as a second-line urate-lowering therapy (ULT) in gout patients with normal renal ...
Swee Gaik Ong, Hui Jen Ding
doaj   +1 more source

Febuxostat Versus Allopurinol Use in Gout Patients: A Real-World Study [PDF]

Cureus
Voskamp J, Tausche A.
europepmc   +3 more sources