Results 21 to 30 of about 9,527 (221)

Evaluation of analgesic activity of allopurinol and febuxostat in experimental analgesic models in mice

Indian Journal of Pain, 2015
Background: Allopurinol and febuxostat are xanthine oxidase inhibitors which are used in the treatment of hyperuricemia and gout. Pain is one of the important symptoms in gout patients.
Promod D Shankpal, J H Hotwani, Kunal A Chitnis, Dnyanesh S Tadke, Vijay R Kokani   +4 more
doaj   +1 more source

Pharmacology and clinical drug candidates in redox medicine [PDF]

, 2015
SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I, Cuadrado, Antonio, Dao, V Thao-Vi, Di Lisa, Fabio, Ghezzi, Pietro, Jaquet, Vincent, Kaludercic, Nina, Maghzal, Ghassan J, Robledinos-Anton, Natalia, Schmidt, Harald H H W, Seredenina, Tamara, Stocker, Roland   +11 more
core   +3 more sources

Febuxostat-induced acute liver injury [PDF]

, 2016
Febuxostat is a unique xanthine oxidase inhibitor that was approved for the prevention of gout in the United States in 2009. Unlike allopurinol, febuxostat is not a nucleoside analogue and has a higher specificity for xanthine oxidase. Although this drug
Matt Bohm, Naga Chalasani, null null, Raj Vuppalanchi   +3 more
core   +2 more sources

Comparative effectiveness of allopurinol versus febuxostat for preventing incident dementia in older adults: a propensity-matched analysis

Arthritis Research & Therapy, 2018
Background The purpose of this study was to assess the comparative effectiveness of allopurinol versus febuxostat for preventing incident dementia in older adults.
Jasvinder A. Singh, John D. Cleveland
doaj   +1 more source

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry [PDF]

, 2014
Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and are attractive drug targets. We have developed a sensitive
A Iphofer, A Kovalenko, A van der Horst, AC Faesen, AK Al-Hakim, AM Oliveira, B Nicholson, C Kondapalli, C Reverdy, D Bungert, D Komander, D Komander, D Komander, DW Lee, E Graner, E Szajli, EW Harhaj, F Colland, F El Oualid, F Ikeda, FE Reyes-Turcu, G Nicastro, H Mistry, HB Kramer, J Chen, J Hemelaar, J Liang, J McCullough, JF McGouran, JW Pierce, K Keusekotten, K Saigoh, L Daviet, LC Dang, LV Pham, M Altun, M Colombo, M Karas, M Li, M Pulvino, MJ Clague, MJ Lee, MK Hospenthal, N Krishnan, NL Anderson, OW Huang, P Cohen, P Rufenacht, R Ekkebus, RA Horton, S Strickson, S Virdee, SD Sherrod, SJ Orcutt, SM Nijman, SM Nijman, SP Shah, TE Messick, TE Mevissen, U Hassiepen, Y Liu, Y Takano, Y Zhang   +62 more
core   +3 more sources

Acute kidney injury in critically ill cancer patients : an update [PDF]

, 2016
Patients with cancer represent a growing group among actual ICU admissions (up to 20 %). Due to their increased susceptibility to infectious and noninfectious complications related to the underlying cancer itself or its treatment, these patients ...
Benoit, Dominique, Lameire, Norbert, Van Biesen, Wim, Vanholder, Raymond   +3 more
core   +2 more sources

A Randomized, Double-Blind, Non-Inferiority Study of Febuxostat Versus Allopurinol in Hyperuricemic Chinese Subjects With or Without Gout

Rheumatology and Therapy, 2019
Introduction This 24-week randomized, double-blind, non-inferiority study compared the efficacy and safety of febuxostat, a xanthine oxidase inhibitor, with allopurinol using an up-titration method in hyperuricemic Chinese subjects with or without gout ...
Fengchun Zhang, Zhichun Liu, Lindi Jiang, Hao Zhang, Dongbao Zhao, Yang Li, Hejian Zou, Xiaoyue Wang, Xiangpei Li, Bingyin Shi, Jianhua Xu, Hongjie Yang, Shaoxian Hu, Shen Qu   +13 more
doaj   +1 more source

Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation. [PDF]

, 2015
Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires intracellular generation of reactive oxygen species (ROS). We present evidence that macrophage secretion of IL1β upon stimulation with ATP, crystals or LPS is mediated by
Busso, N., Ives, A., LeRoy, D., Martinon, F., Miner, J.N., Nomura, J., Roger, T., Simon, G., So, A.   +8 more
core   +1 more source

(Poly)Borylated Species as Modern Reactive Groups toward Unusual Synthetic Applications

Angewandte Chemie, EarlyView.
In this review, we spotlight recent breakthroughs in α‐polyboron‐substituted carbon‐centered intermediates (carbanion, carbocation, radical, and carbene) and polyborylated alkenes. By bridging fundamental reactivity with the application potential of these extraordinary species, we hope this review will serve as a roadmap for harnessing these unique ...
Nadim Eghbarieh, Nicole Hanania, Pinaki Nad, Tipu Alam, Tamir Kish, Ahmad Masarwa   +5 more
wiley   +2 more sources

Efficacy and Safety of Different Doses of Urico-Lowering Agents in The Treatment of Gout with Hyperuricemia: A Systematic Review and Network Meta-Analysis [PDF]

BIO Web of Conferences
Objectives: To systematically evaluate the efficacy and safety of different doses of uric acid- lowering drugs (allopurinol, febuxostat, and benzbromarone) in patients with gout with hyperuricemia by using the method of reticulated Meta-analysis. Methods:
Wen Jie, Wang Yongyan, Li Jialin, Zhang Yiying, Shi Yan, Li Xingzhou, Sun Xuewei   +6 more
doaj   +1 more source