This paper describes an open-source computational tool developed for the modeling and simulation of fed-batch bioreactors, particularly for processes employing Chinese Hamster Ovary (CHO) cells, which are integral to biopharmaceutical manufacturing.
Tilen Gimpelj, Aleksandar Tošić
doaj +3 more sources
Batch and Fed-Batch Fermentation System on Ethanol Production from Whey using Kluyveromyces marxianus [PDF]
Nowadays reserve of fossil fuel has gradually depleted. This condition forces many researchers to find energy alternatives which is renewable and sustainable in the future.
H Hadiyanto +3 more
doaj +3 more sources
Comparison Between Simple Batch and Fed-Batch Bioreactor Cultivation of Recombinant BCG [PDF]
Background/Objectives: Tuberculosis continues to be a significant global health concern, causing 1.3 million deaths in 2022, particularly affecting children under 5 years old.
Sarah Mendes +6 more
doaj +2 more sources
Transferability of bioprocessing modes for recombinant protease production: from fed-batch to continuous cultivation with Bacillus licheniformis [PDF]
Background Proteases are essential in various industries due to their unique substrate specificities and robustness in different operational conditions.
Stefan Kittler +7 more
doaj +2 more sources
Batch-to-Batch Optimization Control of Fed-Batch Fermentation Process Based on Recursively Updated Extreme Learning Machine Models [PDF]
This paper presents a new method of batch-to-batch optimization control for a fed-batch fermentation process. A recursively updated extreme learning machine (ELM) neural network model is used to model a fed-batch fermentation process.
Alex Moore, Jie Zhang
doaj +2 more sources
Modelling of L-valine Repeated Fed-batch Fermentation Process Taking into Account the Dissolved Oxygen Tension [PDF]
This article deals with synthesis of dynamic unstructured model of variable volume fed-batch fermentation process with intensive droppings for L-valine production.
Tzanko Georgiev +4 more
doaj +1 more source
Optimization of Culture Media and Feeding Strategy for High Titer Production of an Adenoviral Vector in HEK 293 Fed-Batch Culture [PDF]
Adenoviruses are efficient and safe vectors for delivering target antigens and adenovirus-based vaccines have been used against a wide variety of pathogens, including tuberculosis and COVID-19.
Chun Fang Shen +4 more
doaj +2 more sources
Probabilistic Bayesian Deep Learning Approach for Online Forecasting of Fed-Batch Fermentation. [PDF]
Wang T +5 more
europepmc +3 more sources
Zeaxanthin Production by an Antarctic Flavobacterium sp.: Effect of Dissolved Oxygen Concentration and Modeling Kinetics in Batch and Fed-Batch Fermentation. [PDF]
Vila E, Ferreira J, Lareo C, Saravia V.
europepmc +2 more sources
Microbial ammonia oxidation is the first and usually rate limiting step in nitrification and is therefore an important step in the global nitrogen cycle. Ammonia-oxidizing archaea (AOA) play an important role in nitrification.
Michael Melcher +6 more
doaj +1 more source

