Results 211 to 220 of about 75,023 (258)

Fed-batch bioproduction of spectinomycin

2007
Actinomycetes produce about 67% of the known antibiotics covering a wide range of chemical structures. However, their filamentous growth present several problems during industrial processes. Among these problems oxygen transfer limitation is critical.
J, Gomes, A S, Menawat
openaire   +2 more sources

Feed Optimization in Fed-Batch Culture

2013
Fed-batch processes are a current preference for the production of recombinant proteins in mammalian cells. The use of nutrient feeding prevents the depletion of important medium components and results in improved culture longevity and high cell and product yields.
Costa, A. R., Rodrigues, E., Henriques, Mariana, Oliveira, Rosário, Azeredo, Joana   +4 more
openaire   +3 more sources

Feedback optimization of fed‐batch fermentation

Biotechnology and Bioengineering, 1987
AbstractThe problem of feedback optimization of the feed rate for fed‐batch fermentation processes is formulated in the framework of singular control theory and switching hypersurfaces. Using four differential balance equations that describe a general class of fedbatch processes and a general objective function to be minimized, it is shown that under ...
J M, Modak, H C, Lim
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Fed-Batch Cultures

2013
Many, if not most, industrially important fermentation and bioreactor operations are carried out in fed-batch mode, producing a wide variety of products. In spite of this, there is no single book that deals with fed-batch operations. This is the first book that presents all the necessary background material regarding the 'what, why and how' of optimal ...
Henry C. Lim, Hwa Sung Shin
openaire   +1 more source

Supervision of fed-batch fermentations

Chemical Engineering Journal, 1999
Process faults may be detected on-line using existing measurements based upon modelling that is entirely data driven. A multivariate statistical model is developed and used for fault diagnosis of an industrial fed-batch fermentation process. Data from several (25) batches are used to develop a model for cultivation behaviour.
Lars Gregersen, Sten Bay Jørgensen
openaire   +1 more source

The Snowball Effect in Fed-Batch Bioreactions

Biotechnology Progress, 2003
The bioreactor will play an important role in future biological manufacturing. For economic profit, important profiles of the feed rate in fed-batch cultures have been discussed. Unfortunately, the optimal feed rate is less robust. In these studies there exists the snowball effect in a substrate-inhibited bioprocess, in which substrate is accumulated ...
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An analysis of extended and exponentially‐fed‐batch cultures

Biotechnology and Bioengineering, 1977
AbstractUnder certain conditions it is shown that an extended culture is equivalent to an exponentially‐fed‐batch culture, that an exponentially‐fed‐batch culture (and an extended culture) can be maintained at a steady state and that an exponentially‐fed‐batch culture may be mimicked by a continuous‐flow culture with a constant dilution rate ...
H C, Lim, B J, Chen, C C, Creagan
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Biological sulphide oxidation in a fed‐batch reactor

Biotechnology and Bioengineering, 1995
AbstractThis study shows that, in a sulphide‐oxidizing bioreactor with a mixed culture of Thiobacilli, the formation of sulphur and sulphate as end‐products from the oxidation of sulphide can be controiledinstantaneously and reversibiy by the amount of oxygen supplied. It was found that at sulphide loading rates of up to 2.33 mmol7/L · h, both products
Janssen, A.J.H., Sleyster, R., van der Kaa, C., Jochemsen, A., Bontsema, J., Lettinga, G.   +5 more
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Fed-Batch Cultivation

2013
Fed-batch reactor is based on feeding of a growth limiting nutrient substrate to a culture. Cell growth and fermentation can be controlled by the feeding strategy. The fed-batch strategy is typically used to reach a high cell density in the bioreactor or mimic a continuous culture. Mostly the feed solution is highly concentrated.
openaire   +1 more source

The control of fed-batch fermentation processes—A survey

Automatica, 1987
A survey of the control of fermentation processes operated in fed-batch mode is presented. Truely optimal conditions can only be found by minimizing (or maximizing) a cost criterion subject ot the constraints imposed by a mathematical model of the process.
openaire   +1 more source