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Zero dynamics of continuous and FED-batch bioreactors
2003 European Control Conference (ECC), 2003The zero dynamics of simple continuous and fed-batch biore-actors is investigated in this paper for different input and output selections. A function λ generating the necessary coordinates transformation has been determined analytically for each case solving a simple PDE, and the resulting coordinates transformations have found to be invertible on the ...
Gábor Szederkényi +2 more
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An adaptive control algorithm for fed‐batch culture
Biotechnology and Bioengineering, 1984AbstractThe implementation of adaptive control for a fed‐batch culture in order to maximize the output of product based on a self‐adjusting model is discussed in the present work. Optimization methods were applied to the generalized mathematical model of a fed‐batch fermentation process to determine control algorithms that could be used for on‐line ...
J, Stanissis, D, Levisauskas
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Reachability of nonlinear fed‐batch fermentation processes
International Journal of Robust and Nonlinear Control, 2002AbstractThe reachability of a simple nonlinear fed‐batch fermentation process model is investigated in this paper. It is shown that the known difficulties of controlling such processes are primarily caused by the fact that the rank of the reachability distribution is always less than the number of state variables.Furthermore, a co‐ordinates ...
Szederkényi, G. +2 more
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2020
The cells used in cell culture processes are all derived from animals. Their genetic and epigenetic control circuits and their physiology have evolved to carry out the physiological functions of the tissue from which they were derived, not to sustain themselves and proliferate in in vitro culture.
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The cells used in cell culture processes are all derived from animals. Their genetic and epigenetic control circuits and their physiology have evolved to carry out the physiological functions of the tissue from which they were derived, not to sustain themselves and proliferate in in vitro culture.
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Glycerol production by fermentation: A fed‐batch approach
Biotechnology and Bioengineering, 1987In this investigation the bioconversion of glycerol from glucose was studied in a laboratory fermentor using an alkaline medium with a fed batch mode of carbon source addition yielding 30% glycerol concentration in the final broth. (Refs. 9).
P, Vijaikishore, N G, Karanth
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Robust adaptive control of yeast fed-batch cultures
Computers & Chemical Engineering, 2008Abstract Model-based control of bioprocesses is a difficult task due to the challenges associated with biological system modeling and the lack of on-line measurements. In this study, two robust controllers using minimal a priori process knowledge and minimal measurement information are designed to maximize biomass productivity in aerobic cultures ...
Renard, Frédéric, Vande Wouwer, Alain
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Adaptive Extremum Seeking Control of Fed-Batch Bioreactors
European Journal of Control, 2003zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Mariana Titica +2 more
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Fed-batch and continuous culture
1990Abstract A variety of techniques has been developed for the submerged culture of microorganisms. Batch and fed-batch culture have been part of the art of fermentation since antiquity and are still used today for most industrial fermentations.
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Optimal nonsingular control of fed‐batch fermentation
Biotechnology and Bioengineering, 1991AbstractPresented is a new simple method for multidimensional optimization of fed‐batch fermentations based on the use of the orthogonal collocation technique. Considered is the problem of determination of optimal programs for fermentor temperature, substrate concentration in feed, feeding profile, and process duration.
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2016
A marked enhancement in the production of cell-bound phytase in Pichia anomala was achieved in cyclic fed batch fermentation (47333 UL-1) in comparison with that in batch (11569 UL-1) and fixed volume fed batch (36911 UL-1) fermentations in cane molasses medium.
Verma, Digvijay, Satyanarayana, T
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A marked enhancement in the production of cell-bound phytase in Pichia anomala was achieved in cyclic fed batch fermentation (47333 UL-1) in comparison with that in batch (11569 UL-1) and fixed volume fed batch (36911 UL-1) fermentations in cane molasses medium.
Verma, Digvijay, Satyanarayana, T
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